Topical treatment and composition

Details Topical treatment and composition Topical treatment and composition

1985-12-27

1987-04-28

Friedman, Stanley J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ketone doai

514730, A61K 3112, A61K 31045

Patent

active

046615245

ABSTRACT:
Pharmaceutical compositions with comprise a compound of the formula (I): ##STR1## wherein X is a chlorine or bromine atom or a methoxyl, methylthio or alkyl group of 1-4 carbon atoms; Y is a --CHR.sub.1 --CH.sub.2 -- or --CR.sub.1 .dbd.CH-- group where R.sub.1 is a hydrogen atom or a methyl group and A is a CHOH or CO group, and a pharmaceutically acceptable carrier selected from the group of creams, ointments, lotions, gels, aerosols, sprays, liniments and gel sticks. The compositions possess systemic anti-inflammatory activity when administered topically.

REFERENCES:
patent: 4126681 (1978-11-01), Reller
patent: 4514386 (1985-04-01), Yamashira et al.
E. A. Boyle et al., "Nabumetone (BRL 14777, 4-[6-Methoxy-2-Naphthyl]-Butan-2-One): A New Anti-Inflammatory Agent," J. Pharm. Pharmacol., 34, pp. 562-569 (1982).
G. B. Fregnan and A. L. Torsello, "Topical Anti-Inflammatory Activity of Dexamethasone 17-Valerate and Other Corticosteroids", Current Therapeutic Research, 17, pp. 375-381 (1975).
R. E. Haddock et al., "Metabolism of Nabumetone (BRL 14777) by Various Species Including Man", Xenobiotica, 14, pp. 327-337 (1984).

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