Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Ester doai
Patent
1993-11-29
1995-10-10
Rose, Shep K.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Ester doai
514546, A61K 31045, A61K 906
Patent
active
054571286
DESCRIPTION:
BRIEF SUMMARY
This is a 371 of PCT/JP93/00379 Mar. 26, 1993.
TECHNICAL FIELD
The present invention relates to a topical preparation for healing wounds of the skin, which can demonstrate remarkable effects of the treatment of wounds of the skin, such as an ulcer of the skin, traumatogenic wounds caused by the abrasion of the skin, traumatogenic wounds caused by the defect of the skin, an ulcer of the crus, zoster, and so on.
BACKGROUND ART
As the era of an extraordinarily advanced age is coming in this country, there is a drastically growing increase year by year in the number of the aged who cannot turn their bodies over or a round in bed by themselves. This undoubtedly increases the number of the aged who suffer from wounds of the skin caused by a stayed in bed without turning over or around. Further, there is the increase in numbers of traumatogenic wounds of the skin caused, for example, by traffic accidents. From such background, growing attention has recently been drawn in various fields to the significance of treating skin diseases. In particular, the skin of the aged is in a state considerably different from that of the young in terms of its structure and functions, and there are many different kinds of skin diseases peculiar to the aged. Unfortunately however, currently drugs highly effective for curing or healing such skin diseases has been developed.
Skin diseases occurring in many cases of the aged who cannot turn over or a round in bed by themselves, include intractable skin ulcers such as, for example, decubitus ulcers, burns caused at low temperature, and so on. Further, the aged poor in a systemic state are likely to have their whole bodies infected with opportunistic viruses including herpes viruses such as, for example, simplex virus, cytomegalo virus, or the like. This systemic infection with such viruses may in many cases accompany various symptoms on the skin, like zoster.
On the other hand, currently, as there are no topical preparations suitable for the treatment of skin diseases with a portion of the skin tissues depressed or for the treatment of skin ulcers caused by circulatory disorders such as buerger, diabetes, phlebothrombosis, and so on, such treatment may suffer from difficulty in many cases.
It can be said that a topical preparation capable of applying a medicament directly to the site of lesion is one of the most superior drug delivery systems for administering such a medicament; however, research and studies on such a drug delivery system for administering topical preparations are less advanced. As things stand today, for instance, it can be said that few medicaments have been developed originally for topical application. As topical preparations, there have been extensively employed adrenocortical hormones as if they are an all-round drug therefor. In fact, the adrenocortical hormones are highly effective for many skin diseases; however, careful attention should be paid to the fact that there are many cases in which the application of the adrenocortical hormones worsens a lesion or symptom of some skin disease, e.g. skin ulcers such as decubitus ulcers, burns, etc., zoster and traumatogenic wounds caused by the abrasion of the skin and by the defect of the skin, and so on. Hence, the adrenocortical hormones should not be randomly applied.
In treating the ulcerated skin diseases such as decubitus ulcers, burns at low temperature and crus ulcers as well as the traumatogenic wounds of the skin, the site of a lesion is sterilized and topical preparations containing a chemical agent are applied for the purpose of a prevention of infection. This therapy is dependent mainly upon the natural curing ability of the living body for curing the lesion and symptom of the skin disease. However, as things stand today, few medicaments can positively and actively cure and heal the lesions and symptoms of the skin diseases. In this country, "Bendazac", or [(1-benzyl-1-H-indazol-3-yl)oxy]acetic acid, is the only one that can be adapted to the treatment of ulcers of the skin. Further, bovine blood ext
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Dott Limited Company
Rose Shep K.
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