Topical pharmaceutical compositions

Details Topical pharmaceutical compositions Topical pharmaceutical compositions

1990-12-19

1992-06-16

Schenkman, Leonard

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514557, 514863, A61K 3119, A61K 31415

Patent

active

051225336

ABSTRACT:
The invention relates to a pharmaceutical composition for removing necrotic skin tissue in mammals, including humans. The composition comprises in combination a substituted thiol in which the hydrogen sulfide moiety is substituted by an organic residue, alantoine, a physiologically acceptable alkaline substance, an application vehicle for the thiol and alkaline constituents, and water for activating the composition. Suitable application vehicles are body giving materials of an oily nature, emulsifiers and a thickening agent, with adequate water to provide the required consistency. Suitable thiols are thioglycolates and similar compounds.

REFERENCES:
patent: 3514515 (1970-05-01), Woolf
patent: 4627934 (1986-12-01), Lindauer et al.
Chemical Abstracts 82:64494q, 1975 (I).
Chemical Abstracts 102:191157p, 1985 (II).

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