Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1986-11-26
1989-05-02
Robinson, Douglas W.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514461, 514544, 514559, 514678, 514701, 514717, 514725, 514915, A61K 3138, A61K 3134, A61K 3107, A61K 3111
Patent
active
048268712
ABSTRACT:
Topical ophthalmic compositions containing one or more retinoids selected from the group consisting of near and remote analogues and derivatives of retinoic acid are described. Six classes of ophthalmic vehicles suitable as carriers for the retinoids are also described. The compositions are useful in the treatment of dry eye syndrome and related ophthalmic surface disorders and as ocular lubricants. A method of treating dry eye syndrome and related ophthalmic surface disorders and a method of providing topical ocular lubrication using these compositions are also described.
REFERENCES:
patent: 3506760 (1970-04-01), Brod
patent: 3843782 (1974-10-01), Krezanoski et al.
patent: 3920810 (1975-11-01), Rankin
patent: 3987163 (1976-10-01), Rankin
patent: 4039662 (1977-08-01), Hecht et al.
patent: 4131651 (1978-12-01), Shah et al.
patent: 4219545 (1980-08-01), Collins
Chem. Abst. 87:102,063m (1977)-Chang et al.
Chem. Abst. 90:203,707s (1979)-Chan et al.
Chem. Abst. 91:117,154y (1979)-Pawson et al.
Chem. Abst. 92:146,995z (1980)-Chan et al.
Chem. Abst. 96: 406u (1982)-Lovey et al.
ArVa-1984-Ubel et al., -3-9:00, "Vitamin A is Present as Retinol in Tears".
Dispersa-Therapeutic Index-Feb. 1981.
Tseng, "Topical Vitamin A Treatment for Dry Eye Disorders", Science Writers Seminar in Ophthalmology, 9-30-10-3, Research to Prevent Blindness, pp. 1-6 (1984).
Sommer et al., "Topical Retinoic Acid in the Treatment of Corneal Xerophthalmia", Am. Journal of Ophthalmology, vol. 86, pp. 615-617 (1978).
Van Horn et al., "Topical Retinoic Acid in the Treatment of Experimental Xerophthalmia in the Rabbit", Archives of Ophthalmology, vol. 99, pp. 317-321, 1981.
Pirie, "Effects of Locally Applied Retinoic Acid on Corneal Xerophthalmia in the Rat", Experimental Eye Research, vol. 25, pp. 297-302 (1977).
Ubels et al., "Healing of Experimental Corneal Wounds Treated with Topically Applied Retinoids", Am. Journal of Ophthalmology, vol. 95, pp. 353-358 (1983).
Smolin et al., "Tretinoin and Corneal Epithelial Wound Healing", Archives of Ophthalmology, vol. 97, pp. 545-546 (1979).
Hatchell et al., "Treatment of Xerophthalmia with Retinol, Tretinoin and Etretinate", Archives of Ophthalmology, vol. 102, pp. 926-927 (1984).
Grosz, "Local Use of Vitamin A Preparations in Ophthalmic Practice", Archives of Ophthalmology, vol. 5, pp. 727-734 (1939).
Sommer, "Treatment of Corneal Xerophthalmia with Topical Retinoic Acid", Am. Journal of Ophthalmology, vol. 95, pp. 349-352 (1983).
Hatchell et al., "Corneal Epithelial Wound Healing in Normal and Diabetic Rabbits Treated with Tretinoin", Archives of Ophthalmology, vol. 103, pp. 98-100 (1985).
Tseng et al., "Topical Retinoid Treatment for Various Dry-Eye Disorders", Ophthalmology, vol. 92, pp. 718-727 (1985).
Edelhauser Henry F.
Gressel Philip D.
Roehrs Robert E.
Ubels John L.
Arno James A.
Brown Gregg C.
Robinson Douglas W.
LandOfFree
Topical ophthalmic compositions containing one or more retinoids does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Topical ophthalmic compositions containing one or more retinoids, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Topical ophthalmic compositions containing one or more retinoids will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-585410