Topical ophthalmic compositions comprising 4-(3-substituted amin

Details Topical ophthalmic compositions comprising 4-(3-substituted amin Topical ophthalmic compositions comprising 4-(3-substituted amin

1993-08-10

1994-06-14

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Topical body preparation containing solid synthetic organic...

Ophthalmic preparation

424 781, 424 7837, 424427, 424428, 514362, 5147726, 514777, 514912, 514913, 544134, A01N 4382, A61K 3141, C07D41708, C07D41712

Patent

active

053208390

ABSTRACT:
Topical ophthalmic compositions comprising certain thiadiazoles are useful in the treatment of glaucoma and ocular hypertension. The thiadiazoles are slightly less potent than timolol; however, they have greatly reduced systemic side effects as compared to timolol.

REFERENCES:
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patent: 4521414 (1985-06-01), Chiou et al.
patent: 4539317 (1985-09-01), Baldwin et al.
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patent: 4623652 (1986-11-01), Erhardt et al.
patent: 4911920 (1990-03-01), Jani et al.
Wasson et al., J. Med. Chem., 15(6):651-655 (1972).
Heel et al., Drugs, 17:38-55 (1979).
L. Bonomi et al., "Comparison of the Effects of Nine Beta-Adrenergic Blocking Agents on Intraocular Pressure in Rabbits," Graefes Archiv Ophthalmologie, vol. 210, 1:1-8 (1979).
Ph. Dorosz' Guide Pratique des Medicaments, 818-819 (1987).
Tocco et al., "Timolol Metabolism in Man and Laboratory Animals," Drug Metabolism and Disposition, vol. 8, 4:236-240.

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