Topical gel containing aminocaproic acid applied to the eye

Details Topical gel containing aminocaproic acid applied to the eye Topical gel containing aminocaproic acid applied to the eye

1995-02-17

1996-04-09

Kishore, Gollamudi S.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Implant or insert

424428, 424 7804, 424450, 514561, 514772, 514912, 514647, 514944, A61K 31195, A61K 9127

Patent

active

055059546

ABSTRACT:
A topical gel formulation containing aminocaproic acid prevents secondary hemorrhage following hyphema without the adverse side effects associated with systemically delivered aminocaproic acid. Of ten human patients treated with the formulation, none have experienced a secondary hemorrhage and none have experienced adverse side effects. The topical gel formulation is prepared by a process which ensures sterility, a pH compatible with conditions in the aqueous humor, and optimum consistency. A permeation enhancer such as proparacaine can be incorporated into the gel during formulation and be used to enhance the transport of aminocaproic acid across the corneal epithelium.

REFERENCES:
Allingham et al Archives of Opthalmology 105, 1987 p. 1421.
Allingham et al Archives of Ophthalmology 106, 1988 p. 1436.
Ehlers et al Invest. Ophthalmology Vis Science 31, 1990, p. 2389.

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