Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1997-08-01
1999-05-18
Jarvis, William R. A.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
A61K31/52
Patent
active
059050810
ABSTRACT:
A method is provided to treat inflammatory bowel disease by topically administering to the colon an effective amount of azathioprine or a pharmaceutically acceptable salt thereof, preferably via formulations adapted for delayed-release oral or rectal administration.
REFERENCES:
patent: 3056785 (1962-10-01), Hitchings et al.
patent: 4350690 (1982-09-01), Kumana
patent: 4627851 (1986-12-01), Wong et al.
patent: 5108758 (1992-04-01), Allwood et al.
Abstract of Japanese Patent Publication No. 62 072618, issued Apr. 3, 1987, (Takada), from Database WPI, Derwent Publications Ltd., London, England.
Adamson, P.C., et al., "A phase II trial of continous-infusion 6-mercaptopurine for childhood solid tumors", Cancer Chemother Pharmacol, 26, 343-344 (1990).
Arndt, C.S., et al., "Bioavailability of low-dose 6-mercaptopurine", Clin. Pharmocol. Ther., 43, 588-591 (May 1988).
Candy, S., et al., "A double-blind controlled study of azathioprine in the treatment and maintenance of remission in Crohn's disease", Gastroenterology, 106, A659 (Apr. 1994).
Caprilli, R., et al., "A double-blind comparison of the effectiveness of azathioprine and sulfasalazine in idiopathic proctocolitis. Preliminary Report", Dig. Dis., 20, 115-120 (1975).
Chan, G.C., et al., "Azathioprine Metabolism: Pharmacokinetics of 6-Mercaptopurine, 6-Thiouric Acid and 6-Thioguanine Nucleotides in Renal Transplant Patients", J. Clin. Pharmacol, 30, 358-363, (1990).
Connell, W.R., et al., "Bone Marrow Toxicity caused by azathioprine in inflammatory bowel disease: 27 years of experience", Gut, 34, 1081-1085 (1993).
Ewe, K., et al., "Azathioprine combined with prednisolone or monotherapy with prednisone in active Crohn's disease", Gastroenterology, 105, 367-372 (Aug. 1993).
Hawthorne, A.B., et al., "Randomised controlled trial of azathioprine withdrawl in ulcerated colitis", Brit. J. Med., 305, 20-22 (1992).
Jewell, D.P., et al., "Azathioprine in ulcerative colitis: final report on controlled therepeutic trial", Br. Med. J., 4, 627-639 (1974).
Kirk, A.P., et al., "Controlled trial of azathioprine in chronic ulcerative colitis", Br. Med. J., 284, 1291-1292 (1982).
Klein, M., et al., "Treatment of Crohn's Disease with Azathioprine: A Controlled Evaluation", Gastroenterology, 66, 916-922 (1974).
Korelitz, B.I., et al., "Favorable Effect of 6-Mercaptopurine on Fistulae of Crohn's Disease", Digestive Diseases and Sciences, 30, 58-64 (Jan. 1985).
Korelitz, B.I., et al., "Shortcomings of the National Crohn's Disease Study: The Exclusion of Azathioprine Without Adequate Trial", Gastroenterology, 80, 193-194 (1981).
Lennard, L., et al., "Azathioprine metabolism in kidney transplant recipients", Br. J. Clin. Pharmac, 18, 693-700 (1984).
Markowitz, J., et al., "Long-Term 6-Mercaptopurine Treatment in Adolescents with Crohn's Disease", Gastroenterology, 99, 1347-1351 (1990).
Nyman, M., et al., "Long-Term Immunosuppresive Treatment in Crohn's Disease", Canadian J. Gastroenterology, 20, 1197-1203 (Nov. 10, 1985).
O'Donoghue, D.P., et al., "Double-Blind Withdrawl Trial of Azathioprine as Maintenance Treatment for Crohn's Disease", The Lancet, 955-957 (Nov. 4, 1978).
Odlind, B., et al., "Serum Azathioprine and 6-Mercaptopurine Levels and Immunosuppresive Activity after Azathiprine in Uremic Patients", Int. J. Immunoopharmac, 8, 1-11 (1986).
Perrault, J., et al., "6-Mercaptopurine Therapy in Selected Cases of Corticosteriod-Dependent Crohn's Disease", May Clin. Proc., 66, 480-484 (1991).
Present, D.H., et al., "6-Mercaptopurine in the Management of inflammatory Bowel Disease: Short and Long Term Toxicity", Annals of Internal Medicine, 111, 641-649 (Oct. 15, 1989).
Present, D.H., et al., "Treatment of Crohn's Disease with 6-Mercaptopurine", N. Eng. J. Med., 302, 981-987 (May 1, 1980).
Rhodes, J., et al., "Controlled Trial of Azathioprine in Crohn's Disease", The Lancet, 1273-1276 (Dec. 11, 1971).
Rosenberg, J.L., et al., "A controlled trial of azathioprine in the management of chronic ulcerative colitis", Gastroenterology, 69, 96-99 (1975).
Rosenberg, J.L., et al., "A Controlled Trial of Azathiprine in Crohn's Disease", Digestive Disease, 20, 721-726 (Aug. 1975).
Singleton, J.W., "Azathioprine Has a Very Limited Role in the Treatment of Crohn's Disease", Digestive Diseases and Sciences, 26, 368-371 (Apr. 1981).
Summers, R.W., et al., "National Cooperative Crohn's Disease Study: Results of Drug Treatment", Gastroenterology, 77, 847-869 (1979).
Sutherland, L.R., "Topical treatment of ulcerative colitis", Med. Clin. North Am., 74, 119-131 (Jan. 1990).
Takeichi, Y., et al., "Improvement of aquenous solubility and rectal absorption of 6-mercaptopurine by addition of sodium benzoate", Biol. Pharm. Bull., 17, 1391-1394 (Oct. 1994).
Verhave, M., et al., "Azathioprine in the treatment of children with inflammatory bowel disease", J. Pediatrics, 177, 809-814 (Nov. 1990).
Willoughby, J.T., et al., "Controlled Trial of Azathioprine in Crohn's Disease", The Lancet, 944-946, (Oct. 30, 1971).
Wilson, E.P., et al., "Azathioprine", Analytical Profiles of Drug substances, vol. 10; K. Florey, Ed; Academic Press: New York, 30-53, (1981).
Zimm, S., et al., "Phase I and Clincial Pharmacological Study of Mercaptopurine Administered as a Prolonged Intravenous Infusion", Cancer Research, 45, 1869-1873 (Apr. 1985).
Zimm, S., et al., "Variable Bioavailability of Oral Mercaptopurine", N. Eng. J. Med., 308, 1005-1009 (1983).
Jarvis William R. A.
Mayo Foundation for Medical Education and Research
LandOfFree
Topical formulations of azathioprine to treat inflammatory bowel does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Topical formulations of azathioprine to treat inflammatory bowel, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Topical formulations of azathioprine to treat inflammatory bowel will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1759627