Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...
Patent
1999-04-09
2000-11-07
Criares, Theodore J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Nitrogen containing other than solely as a nitrogen in an...
A61K 3113, A61K 31135
Patent
active
061437948
ABSTRACT:
Stable, topical formulations useful for treating a nail fungal disease are disclosed. The compositions comprise an antifungal compound and at least one pharmaceutically acceptable excipient sufficient to form a gel. The antifungal compound is represented by the formula ##STR1## where R.sup.1, R.sup.2, and R.sup.3 are independently hydrogen or lower alkyl; X is --(CH.sub.2).sub.n -- in which n is 0, 1 or 2; Y is aryl or heteroaryl; and Ar is aryl or heteroaryl. The composition is applied to the afflicted nail for once a day until the fungal disease is cured.
REFERENCES:
patent: 4079028 (1978-03-01), Emmons et al.
patent: 4155892 (1979-05-01), Emmons et al.
patent: 4746509 (1988-05-01), Haggiage et al.
patent: 4822822 (1989-04-01), Arita et al.
patent: 4957730 (1990-09-01), Bohn et al.
patent: 4962178 (1990-10-01), Harisiades
patent: 4971800 (1990-11-01), Chess et al.
patent: 5002938 (1991-03-01), Wang et al.
patent: 5021458 (1991-06-01), Maeda et al.
patent: 5045317 (1991-09-01), Chess et al.
patent: 5051260 (1991-09-01), Chess et al.
patent: 5106866 (1992-04-01), Maeda et al.
patent: 5286787 (1994-02-01), Podola et al.
patent: 5322685 (1994-06-01), Nakagawa et al.
patent: 5334628 (1994-08-01), Maeda et al.
patent: 5639740 (1997-06-01), Crandall
patent: 5696164 (1997-12-01), Sun et al.
patent: 5916545 (1999-06-01), Burnett et al.
Hisamitsu Pharmaceutical Co., Inc., "JP 07 206711: Composition for Treatment of Trichophytosis Unguium," Patent abstracts of Japan, vol. 095, No. 011, Dec. 26, 1995.
Hisamitsu Pharmaceutical Co., Inc., "JP 06 211651: Composition for Treatment Nail Trichophytosis," Patent Abstracts of Japan, vol. 018, No. 575, Nov. 04, 1994.
Miyata et al, "External Preparation for Nail Ringworm,"Chemcial Abstracts, vol. 125, No. 6, Abstract No. 67762, 1996.
Syed et al., "Management of Toenail Onychomycosis with 2% Butenafine and 20% Urea Cream: A Placebo-controlled, Double-blind Study," Journal of Dermatology, vol. 25, pp. 648-652, 1998.
Meyerson, "Open-label Study of the Safety and Efficacy of Naftifine Hydrochloride 1 Percent Gel in Patients with Distal Subungual Onychomychosis of the Fingers", Therapeutics for the Clinician, vol. 51, pp. 205-207, Mar. 1993.
Saunders, "Polyurethanes: Chemistry and Technology, vol. 16, pp. 65-67, Interscience Publishers", 1962.
Bucks Daniel
Chaudhuri Bhaskar
Chim Ming Fai
Bertek Pharmaceuticals, Inc.
Criares Theodore J.
Kim Jennifer
LandOfFree
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