Topical drug release system

Details Topical drug release system Topical drug release system

1985-01-23

1988-08-30

Schenkman, Leonard

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Cyclopentanohydrophenanthrene ring system doai

514561, 514570, 514629, 514721, 514937, 514944, A61K 3156

Patent

active

047677511

ABSTRACT:
A pharmaceutical composition for topical administration consisting of two liquid phases designed to be admixed in situ or prior to use. The first phase contains a dissolved drug, and is preferably saturated in the drug, while the second phase is a chemically or physically different liquid from that in the first phase and contains no drug, but is miscible with the first phase. The two liquids are selected so that, on admixture of suitable volumes of the phases, the resultant drug concentration exceeds the saturated drug solubility in the resultant mixture. This produces a liquid mixture supersaturated in drug, which has been found to increase the rate of drug penetration into the skin. The two liquid phases may be gels, and the drug may be hydrocortisone.

REFERENCES:
patent: 4140656 (1979-02-01), Mast
patent: 4244942 (1981-01-01), Kamishita et al.
patent: 4602040 (1986-07-01), Belsoce
Coldman et al., J. Pharm. Sci., vol. 58, No. 9(1969), pp. 1098-1102.
Umer, Chem. Abst., 97, 188191t (1982).

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