Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Cyclopentanohydrophenanthrene ring system doai
Patent
1987-12-10
1990-07-10
Schenkman, Leonard
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Cyclopentanohydrophenanthrene ring system doai
514937, A61K 3156
Patent
active
049407015
ABSTRACT:
A pharmaceutical composition for topical administration consisting of two liquid phases designed to be admixed in situ or prior to use. The first phase contains a dissolved drug, and is preferably saturated in the drug, while the second phase is a chemically or physically different liquid from that in the first phase and contains no drug, but is miscible with the first phase. The two liquids are selected so that, on admixture of suitable volumes of the phases, the resultant drug concentration exceeds the saturated drug solubility in the resultant mixture. This produces a liquid mixture supersaturated in drug, which has been found to increase the rate of drug penetration into the skin. The two liquid phases may be gels, and the drug may be hydrocortisone.
At least one phase contains an antinucleant to improve stability of the resulting supersaturated solution.
REFERENCES:
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patent: 3953591 (1976-04-01), Snyder
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patent: 4244942 (1981-01-01), Kamishita et al.
patent: 4602040 (1986-07-01), Belsoce
patent: 4695464 (1987-09-01), Alderman
patent: 4767751 (1988-08-01), Davis
Beecham Group p.l.c.
Schenkman Leonard
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