Topical drug delivery with polyoxyalkylene polymer thermoreversi

Details Topical drug delivery with polyoxyalkylene polymer thermoreversi Topical drug delivery with polyoxyalkylene polymer thermoreversi

1992-06-09

1994-03-29

Webman, Edward

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Matrices

514944, 523105, 523122, 2523151, A61K 910, A61K 4734

Patent

active

052982602

ABSTRACT:
Iso-osmotic, hyperosmotic, or hypo-osmotic, pH balanced, thermoreversible gels are ideal medical devices or vehicles for drug delivery to the skin of a mammal. The osmolality in the gel state can be calculated by assuming that a polyoxyalkylene block copolymer or polyether present in said gel does not contribute to the osmolality in the gel state, although it does contribute to the measured osmolality in the liquid state.

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Schmolka, I. R., "Artificial Skin I Preparation and Properties of PLURONIC.RTM. F-127 Gels For Treatment of Burns", Journal of Biomedical Material Research, vol. 6 p. 571 (1972).

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