Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Web – sheet or filament bases; compositions of bandages; or...
Patent
1993-07-12
1995-05-16
Page, Thurman K.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Web, sheet or filament bases; compositions of bandages; or...
424443, 424447, 514817, 602 48, 604304, 604307, A61K 970, A61F 1302
Patent
active
054158664
ABSTRACT:
A drug delivery system for the topical administration of medication which utilizes a viscoelastic gel pad having a liquid fraction, wherein the medication is incorporated within the liquid fraction, the viscoelastic gel pad being partially encapsulated between two layers of liquid fraction impermeable material which are joined together to form a seal about the periphery of the gel pad so as to control migration of the pad, and the medicating skin contact of the pad is limited to a drug delivery aperture formed in the skin-contacting layer of liquid fraction impermeable material. The aperture-containing layer, which contacts a wearer's skin, may be provided with a pressure sensitive adhesive. The invention is exemplified in a topical anesthetic delivery system wherein a viscoelastic gel pad, partially encapsulated by transparent alcohol and water impermeable layers, has an alcohol and water liquid fraction in which is dissolved lidocaine base. The alcohol and liquid fraction of the anesthetic viscoelastic gel pad may be from 20% to 90% alcohol, preferably 70% ethyl alcohol, wherein is dissolved 10% to 40%, by weight, of Lidocaine U.S.P./N.F. Such topical anesthetic drug delivery system can be preliminarily applied with accuracy to a target skin surface by a patient, leaving, upon subsequent removal, a target skin surface anesthetized and ready for immediate dermal surgery or other treatment.
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Ingman John F.
Page Thurman K.
Spear James M.
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