Surgery – Means for introducing or removing material from body for... – Treating material applied to or removed from external...
Patent
1985-03-14
1987-08-18
Rosenbaum, C. Fred
Surgery
Means for introducing or removing material from body for...
Treating material applied to or removed from external...
128156, 206484, A61F 1302
Patent
active
046874763
DESCRIPTION:
BRIEF SUMMARY
FIELD OF THE INVENTION
This invention relates to dressings for use in the topical administration of substances, particularly therapeutic substances.
BACKGROUND ART
It is known to administer drugs transdermally i.e. by maintaining a drug in intimate contact with a patient's skin so that the active constituent slowly passes through the skin and is absorbed into the patient's body over a prolonged period of time.
The drug is usually held in position for the requisite period of time using an adhesive patch, the drug being incorporated as an integral part of the patch for example by admixture with the adhesive. However, the problem arises that such patches can be inconvenient or difficult to manufacture especially where mass-production of different patches containing different drugs is required.
DISCLOSURE OF THE INVENTION
An object of the present invention is to overcome or at least minimise this problem.
According to the invention therefore there is provided a method of manufacturing topical dressings utilising a continuous strip-shaped assembly having successive longitudinally spaced locations respectively for receiving and retaining thereat a topical substance, characterised in that said locations comprise apertures in a protected layer of skin adhesive provided on one side of said assembly and a continuous length of sealing foil is applied to the opposite side thereof, said assembly being separable between said apertures into individual dressing structures each comprising a respective said aperture bounded on one side by said adhesive and sealed at its opposite side by said foil.
With this method the use of continuous lengths of material can much facilitate the manufacturing process, especially on a mass-production basis. Moreover, this advantage can be achieved essentially irrespective of the nature of the topical substance in so far as incorporation of such substance can be effected independently of the fabrication of the dressing structures by insertion thereof into the said preformed receiving apertures in a particularly simple and convenient manner.
The method of the invention may be utilised in the production of dressings for transdermal drug application. It is however to be understood that the invention is not intended to be restricted to this field of application and may find use in the context of therapeutic substances, such as skin creams, not necessarily required to be absorbed through the patient's skin, or even cosmetics or fragrances or other non-therapeutic substances. Moreover, the invention may be utilised in the manufacture of dressings for animal as well as human use.
The adhesive may be applied to a layer of absorbent microporous material (e.g. polyamide fabric) having slow release properties, the said apertures being arranged to pass through this material as well as the adhesive.
The adhesive may be any suitable hypoallergenic adhesive as customarily used on the skin and this may be provided with a protective peel-off backing film such as a siliconised paper such paper having holes therein in alignment with the apertures. A laminated strip comprising continuous layers of said microporous material, said adhesive and said backing paper, may be appropriately die-cut to define said protected adhesive bounded apertures.
With regard to the said foil this may be formed from a polyester/metal foil composite or other material which is thin, flexible and generally of an impervious nature. Such foil may be heat-welded in position (e.g. to the said microporous material) for example by heat fusion of a polyethylene film on the foil material.
The assembly produced with the method of the invention may be separated into individual dressing structures, for example by transverse tearing or cutting between the said locations, and then enclosed between sheets, for example clear plastics sheets, after insertion of therapeutic or other topical substances into the said receiving locations, thereby to define storable sachets which are to be opened prior to use. To facilitate said separation into the dr
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patent: 4127339 (1978-10-01), Malacheski et al.
patent: 4376483 (1983-03-01), Sullivan
Rosenbaum C. Fred
Smith, Jr. Jerome R.
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