Topical dressing

Details Topical dressing Topical dressing

1996-08-22

1998-06-30

Kishore, Gollamudi S.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Web, sheet or filament bases; compositions of bandages; or...

424448, 424449, A61F 1302, A61K 970, A61L 1516

Patent

active

057730229

DESCRIPTION:

BRIEF SUMMARY
FIELD OF THE INVENTION

The invention is related to a topical dressing for dermal or transdermal administration of a substance, comprising the features of the preamble of claim 1.
The invention is also related to a method of manufacturing the topical dressing for dermal or transdermal administration according to the invention.


BACKGROUND OF THE INVENTION

This invention relates to dressings for use in the topical administration of drugs and other substances.
It is known to administer drugs dermally and transdermally i.e. by maintaining a drug in intimate contact with a patients skin so that the active constituent slowly passes into and through the skin and is absorbed into the patient's body over a prolonged period of time.
The drug is usually held in position for the requisite period of time using an adhesive patch.
EP-A-0013606 describes an adhesive patch for transdermal drug administration which comprises a laminated backing strip shaped to provide a cavity which is filled with a polymeric matrix containing the drug to be administered. The cavity is bounded with skin adhesive and is sealed by a laminated cover strip which is held in position by the adhesive. The cover strip is provided with a surface layer of release material so that it can be readily separated from the backing strip to expose the polymeric diffusion matrix and the skin adhesive for use.
EP-B-0181333 describes an adhesive patch for transdermal administration which comprises a backing strip having a ring of microporous material fixed to a support sheet which is a polyethylene/metal foil/polyester laminate. The ring of microporous material has a surface layer of skin adhesive and defines a central cavity which contains the drug to be administered. A cover strip is formed from the same laminated material as the above mentioned support sheet and is held in position to seal the cavity by engagement of a release layer on the surface of the cover strip with the skin adhesive, and by means of a heat seal ring between the laminated materials of the backing strip and the cover strip beyond the outer periphery of the ring of microporous material. The drug in the cavity and the skin adhesive are exposed for use by separating a portion of the lamination material of the backing strip with the attached ring of microporous material by tearing the laminated material around a ring of perforations.
With the above mentioned known constructions sealing of the cavity is achieved by virtue of the engagement between the layer skin adhesive on the backing strip and the release layer on the cover strip, and in the case of EP-B-0181333 also by means of the outer heat seal ring. With this arrangement there is the problem that the drug in the cavity may at least partially escape, e.g. by diffusion into the surrounding adhesive and/or other layers, especially if the drug is of a mobile or volatile nature, and particularly if the drug is present in the cavity by itself or absorbed on a pad or otherwise in readily releasable form rather than being incorporated in a rotentive medium such as the polymeric matrix of EP-A-0013606. Since transdermal dressings may be used for accurate administration of predetermined quantities of drugs it will be appreciated that escape of quantities of the drug from the cavity can constitute a serious problem.
A topical dressing of the above mentioned type is also described in Australian Patent Application No. 75975/91. This dressing is provided with a backing layer which contains a backing sheet which only partly covers the resilient layer.
In the above mentioned Australian dokument the backing sheet is provided as single pieces of backing which, during production, are intended to be placed, one by one, on the continuous layer of resilient material at predetermined positions. This is a procedure which however gives raise to a new problem. Because the backing sheet is made of a very thin material, about 10-50.mu.m, the edges of the pieces of backing will bend upwards which makes the application of the discs on the resilient structure mor

REFERENCES:
patent: D377529 (1997-01-01), Nyqvist-Mayer
patent: 3900027 (1975-08-01), Keedwell
patent: 4695277 (1987-09-01), Lauk
patent: 4849224 (1989-07-01), Chang et al.
patent: 4915102 (1990-04-01), Kwiatek et al.
patent: 5268179 (1993-12-01), Rudella
Dialog abstract of German patent document DE 3204582 (listed above as document AM1), Derwent World Patents Index accession No. 83-747746/35.
Dialog abstract of Norwegian patent document NO 163438 (listed above as document ANI), Derwent World Patents Index accession No. 86-049686/08.

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