Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector
Reexamination Certificate
2007-09-07
2010-06-08
Mosher, Mary E (Department: 1648)
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
C424S278100, C424S400000, C424S489000, C514S04400A
Reexamination Certificate
active
07731968
ABSTRACT:
The present invention provides improved methods for delivery of substances into the skin. It has been discovered that delivery of substances such as nucleic acids, amino acids, amino acid derivatives, peptides and polypeptides simultaneously with abrasion of the skin enhances delivery and the biological response as compared to application of the substance to previously abraded skin.
REFERENCES:
patent: 3289670 (1966-12-01), Kurg et al.
patent: 3351059 (1967-11-01), Kravitz
patent: 3556080 (1971-01-01), Hein
patent: 3964482 (1976-06-01), Gerstel et al.
patent: 4270548 (1981-06-01), Brennan
patent: 4483348 (1984-11-01), Sher
patent: 4568343 (1986-02-01), Leeper et al.
patent: 4746515 (1988-05-01), Cheng et al.
patent: 5003987 (1991-04-01), Grinwald
patent: 5273528 (1993-12-01), Skeen et al.
patent: 5380337 (1995-01-01), Romaine
patent: 5501784 (1996-03-01), Lessmollmann et al.
patent: 5611806 (1997-03-01), Jang
patent: 5620896 (1997-04-01), Hermann et al.
patent: 5658515 (1997-08-01), Lee et al.
patent: 5660680 (1997-08-01), Keller
patent: 5679647 (1997-10-01), Carson et al.
patent: 5848991 (1998-12-01), Gross et al.
patent: 5855801 (1999-01-01), Lin et al.
patent: 5879326 (1999-03-01), Godshall et al.
patent: 5885211 (1999-03-01), Eppstein et al.
patent: 5910306 (1999-06-01), Alving et al.
patent: 5919364 (1999-07-01), Lebouitz et al.
patent: 5928207 (1999-07-01), Pisano et al.
patent: 5931794 (1999-08-01), Pitesky
patent: 5958589 (1999-09-01), Glenn et al.
patent: 5964729 (1999-10-01), Choi
patent: 5970998 (1999-10-01), Talbot et al.
patent: 5980898 (1999-11-01), Glenn et al.
patent: 5983136 (1999-11-01), Kamen
patent: 6015599 (2000-01-01), Keller et al.
patent: 6032060 (2000-02-01), Carim et al.
patent: 6050988 (2000-04-01), Zuck
patent: 6065864 (2000-05-01), Evans et al.
patent: 6106751 (2000-08-01), Talbot et al.
patent: 6132755 (2000-10-01), Eicher et al.
patent: 6173202 (2001-01-01), Eppstein
patent: 6183434 (2001-02-01), Eppstein
patent: 6187210 (2001-02-01), Lebouitz et al.
patent: 6256533 (2001-07-01), Yuzhakov et al.
patent: 6299900 (2001-10-01), Reed et al.
patent: 6312612 (2001-11-01), Sherman et al.
patent: 6331266 (2001-12-01), Powell et al.
patent: 6334856 (2002-01-01), Allen et al.
patent: 6454755 (2002-09-01), Godshall
patent: 6623457 (2003-09-01), Rosenberg
patent: 6835184 (2004-12-01), Sage et al.
patent: 0381410 (1990-08-01), None
patent: 05091222 (1994-04-01), None
patent: 1086719 (2001-03-01), None
patent: 1092444 (2001-04-01), None
patent: 2125280 (1924-08-01), None
patent: 1724181 (1994-04-01), None
patent: WO9607369 (1996-03-01), None
patent: WO9703718 (1997-02-01), None
patent: WO9711650 (1997-04-01), None
patent: WO9748440 (1997-12-01), None
patent: WO9748442 (1997-12-01), None
patent: WO9900155 (1999-01-01), None
patent: WO9943350 (1999-09-01), None
Degano et al., “Intradermal DNA Immunization of mice against influenza A virus using the novel Powderject system,” Vaccine, vol. 16, No. 4 (1998).
Iwasaki et al., “Epitope-specific cytoxic T lymphocyte induction by minigene DNA immunization,” Vaccine 17(15-16):2081-8 (1999).
Robinson, “DNA vaccines: basic mechanism and immune responses,” Int J Mold Med 4(5):549-55 (1999).
Definition from Wikipedia, Apr. 22, 2006.
MJ. McCluskie et al., Molecular Medicine, 5:287, 1999.
Skin Immunization Made Possible by Cholera Toxin, Nature, vol. 391, Feb. 26, 1998,p. 851.
Tuberculin, Old Mno-Vacc Test (O.T.), product information, www.us.aventispasteur.com., (1991).
E.Raz et al., Intradermal Gene Immunization: The Possible Role of DNA Uptake in the Induction of Cellular Immunity to Viruses, Proc. Natl.Acad. Sci., USA 91 (1994).
D.A. Greenhalgh et al., Epidermis: An Attractive Target Tissue for Gene Therapy, Journal of Investigative Dermatology, vol. 108, No. 5, May 1997.
M. Yokohama et al., DNA Immunization: Effects of Vehicle and Route of Administration on the Induction of Protective Antriviral Immunity, FEMS Immunology and Medical Microbioligy 14 (1996) 221-230.
L. Li et al., the Feasibility of Targeted Selective Gene Therapy of the Hair Follicle, Nature Medicine, vol. 1, No. 7, Jul. 1995, p. 705-706.
D. Tang, Vaccination onto Bare Skin, Nature, vol. 388, Aug. 21, 1997, p. 729.
Wm.C.Brown Publishers, Van De Graff, et al., Concepts of Human Anatomy and Physiology, pp. 197-1999 (1986) USA.
Alarcon Jason
Brittingham John M.
Dekker, III John P.
Mikszta John A.
Pettis Ronald J.
Becton Dickinson and Company
Mosher Mary E
West Robert E.
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