Topical delivery of L-arginine to cause tissue warming

Details Topical delivery of L-arginine to cause tissue warming Topical delivery of L-arginine to cause tissue warming

1997-09-17

1999-04-20

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Cosmetic, antiperspirant, dentifrice

424450, A61K 600, A61K 700

Patent

active

058956581

ABSTRACT:
A preparation is disclosed for producing enhanced blood flow in tissue thus causing beneficial effects such as warming cold tissue of the hands and feet. Specifically, this is a preparation which provides local delivery of the amino acid L-arginine, an important biological precursor to the main substance which is responsible for relaxation of blood vessels permitting enhancement of blood flow. In the preferred embodiments, the L-arginine is provided so that it can be topically applied to the cold tissue. The preparation also contains agents which aids in the transfer of L-arginine into the tissue. In the preferred embodiments this agent overcomes the resistance to transfer caused by the high charge density of L-arginine. In the preferred embodiments this means is high ionic strength created by addition of choline chloride, magnesium chloride and sodium chloride. This preparation, when topically applied to cold tissue, warming begins within about 10 to 45 minutes and is sustained for periods as long as about 2 to 18 hours.

REFERENCES:
patent: 4681897 (1987-07-01), Brand
patent: 5595753 (1997-01-01), Hechtman
Pauly et al., Chemical Abstracts, vol. 113, #65,069, 1990.
Riedel et al., Chemical Abstracts, vol. 122, #130053, 1996.

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