Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Cosmetic – antiperspirant – dentifrice
Patent
1997-09-17
1999-07-13
Page, Thurman K.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Cosmetic, antiperspirant, dentifrice
424450, A61K 600, A61K 700
Patent
active
059223324
ABSTRACT:
The use of a topical preparation for producing enhanced levels of the precursor of the endogenous analgesic kyotorphin for the purpose of overcoming pain is disclosed. Specifically, use of a topical preparation provides local delivery of the amino acid L-arginine, an important biological precursor to the main substance which is responsible for relaxation of blood vessels permitting enhancement of blood flow. In the preferred embodiments, the L-arginine is provided so that it can be topically applied to the area of pain. The preparation also contains an agent which aids in the transfer of L-arginine into the tissue. In the preferred embodiments this agent overcomes the resistance to transfer caused by the high charge density of L-arginine. In the preferred embodiments this means is high ionic strength created by addition of sodium chloride. Other preparations containing, in addition to L-arginine, substances which overcome pain by other mechanisms such as capsaicin which depletes sensory fibers of substance P constitutes an additional embodiment. These preparations, when topically applied to the area of pain overcomes pain.
REFERENCES:
patent: 4681897 (1987-07-01), Brand
patent: 5595753 (1997-01-01), Hechtman
Pauly et al., Chemical Abstracts, vol. 113 #65069, 1990.
Howard Sharon
Page Thurman K.
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