Topical containing aminocaproic acid for preventing secondary he

Details Topical containing aminocaproic acid for preventing secondary he Topical containing aminocaproic acid for preventing secondary he

1994-04-06

1995-05-16

Kishore, Gollamudi S.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Implant or insert

424428, 424 7804, 424450, 514561, 514772, 514912, 514647, 514944, A61K 31195, A61K 9127

Patent

active

054158630

ABSTRACT:
A topical gel formulation containing aminocaproic acid prevents secondary hemorrhage following hyphema without the adverse side effects associated with systemically delivered aminocaproic acid. Of ten human patients treated with the formulation, none have experienced a secondary hemorrhage and none have experienced adverse side effects. The topical gel formulation is prepared by a process which ensures sterility, a pH compatible with conditions in the aqueous humor, and optimum consistency. A permeation enhancer such as proparacaine can be incorporated into the gel during formulation and be used to enhance the transport of aminocaproic acid across the corneal epithelium.

REFERENCES:
patent: 5137728 (1992-08-01), Bawa
patent: 5145680 (1992-09-01), Hayashi
Ehlers et al. Invest. Ophthalmology & Vis. Sciac, 31, 1990, p. 2389.
Allingham et al., Archives of Ophthalmology, vol. 105, 1987, p. 1421.
Allingham et al., Archives of Ophthalmoly, 106, 1988, p. 1436.
Loewy et al., "Systemic Aminocaproic Acid Reduces Fibrinolysis in Aqueous Humor", Arch. Ophthalmol., vol. 105, pp. 272-276 (Feb. 1987).
Allingham et al., "Topically Applied Aminocaproic Acid Concentrates in the Aqueous Humor of the Rabbit in Therapeutic Levels", Arch. Ophthalmol., vol. 105, pp. 1421-1423 (Oct. 1987).
Allingham et al., "Topical Aminocaproic Acid Significantly Reduces the Indidence of Secondary Hemmorrhage in Traumatic Hyphema in the Rabbit Model", Arch. Ophthalmol., vol. 106, pp. 1436-1438 (Oct. 1988).
Ehlers et al., "Factors Affecting Therapeutic Concentration of Topical Aminocaproic Acid in Traumatic Hyphema", Invest. Ophthalmol. Vis. Sci., vol. 31, No. 11, pp. 2389-2394 (Nov. 1990).

Affiliated with

Also associated with

Rating

Topical containing aminocaproic acid for preventing secondary he does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Topical containing aminocaproic acid for preventing secondary he, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Topical containing aminocaproic acid for preventing secondary he will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-636379