Topical compositions useful as skin penetration barriers

Details Topical compositions useful as skin penetration barriers Topical compositions useful as skin penetration barriers

1993-08-04

2000-07-11

Levy, Neil

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Biocides; animal or insect repellents or attractants

424 59, 424 709, 574376, A01N 2532

Patent

active

060869054

ABSTRACT:
Methods for preventing the penetration of toxic chemicals through the stratum corneum of the skin of a mammal are disclosed which employ, as a penetration prevention agent, at least one compound selected from the group consisting of compounds represented by the formula: ##STR1## wherein W.sub.1 is a divalent oxygen, sulfur or nitrogen radical, W.sub.2 and W.sub.3 are independently a divalent oxygen or sulfur radical, R' is an alkyl radical comprising from 1 to 4 carbon atoms, y is 0 or 1, R.sub.1 and R.sub.2 are alkyl radicals comprising from 1 to 10 carbon atoms and R and R.sub.3 are individually a hydrocarbyl radical containing from 1 to 20 carbon atoms or a heteroatom-substituted derivative thereof wherein at least one but not two adjacent carbon atoms may be replaced by a divalent oxygen or sulfur radical or by NR", wherein R" is hydrogen or R', n is an integer from 2 to 5 and compounds represented by the above formula in which the ring and/or R includes one to three carbon carbon double bonds.

REFERENCES:
patent: 3100180 (1963-08-01), Smith et al.
patent: 4960771 (1990-10-01), Rajadhyaksha
patent: 5091379 (1992-02-01), Aungst
Brain, K.R. et al., Abstract of "Electrostatic Factors in the Activity of Penetration Enhancers," presented at the Third International Prediction of Percutaneous Penetration Conference held in La Grande Motte, Apr. 1993.
Bronaugh, R.L. et al., "Vehicle Effects on Percutaneous Absorption: in vivo and in vitro Comparisons with Human Skin," British Journal of Dermatology 115: 1-11 (1986).
Franz, T.J., "The Finite Dose Technique as a Valid in vitro Model for the Study of Percutaneous Absorption in Man," Curr. Probl. Dermatol. 7: 58-68 (1978).
Hadgraft, J. et al., "Investigations on the Percutaneous Absorption of the Antidepressant Rolipram in vitro and in vivo," Pharmaceutical Research 7(12) : 1307-1312 (1990).
Williams, D. G., "Mechanisms of Action of Penetration Enhancers," Ph.D. Thesis, University of Wales, 1991.

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