Topical compositions for re-epithelialization of persistent epit

Details Topical compositions for re-epithelialization of persistent epit Topical compositions for re-epithelialization of persistent epit

1994-09-26

1996-07-30

Travers, Russell

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Radical -xh acid, or anhydride, acid halide or salt thereof...

A61K 31195

Patent

active

055412262

ABSTRACT:
Persistent epithelial defects are effectively treated by topically applying a gelatinous composition containing either aminocaproic acid or tranexamic acid to the eye. In vivo results demonstrate improved healing of the epithelium and basement membrane complex. The gelatinous composition is prepared by a process that ensures sterility and proper pH conditions throughout the gel.

REFERENCES:
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R. R. Allingham et al., "Topical Aminocaproic Acid Significantly Reduces the Incidence of Secondary Hemorrhage in Traumatic Hyphema in the Rabbit Model," Laboratory Sciences, 106, 1436-1438 (Oct. 1988).
H. E. Kaufman et al., eds., The Cornea, Churchill Livingstone, "Corneal Trauma," pp. 619-621 (1988).
H. M. Leibowitz, ed., Corneal Disorders, Clinical Diagnosis and Management, W. B. Saunders Company, pp. 222-227 (1984).
W. Tasman et al., ed., Duane's Clinical Ophthalmology, J. B. Lippincott Company, pp. 1-22, Revised Edition (1993).
Robert C. Arffa; "Epithelial Diseases, Chapter 15;" Grayson's Diseases of the Cornea; Kimberly Kist, ed.; 324-332 (1991).
Ramon R. Berrios et al., "Traumatic Hyphemia," International Ophthalmology Clinics, Trauma, 35, 93-103 (1995).
Alvina M. Janda, "Ocular Trauma--Triage and Treatment," Postgraduate Medicine, 90, 51-52, 55-57, 59-60 (Nov. 15, 1991).
Bradford Shingleton, "Eye Injuries," The New England Journal of Medicine, 325, 408-413 (Aug. 8, 1991).
M. Verstraete, "Clinical Application of Inhibitors of Fibrinolysis," Drugs--Focus on Flecainide and Terfenadine--Multiple Sclerosis Diuretics: A Review, 29 236-261 (Jan. 1985).

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