Drug – bio-affecting and body treating compositions – Designated organic nonactive ingredient containing other... – Carboxylic acid ester
Patent
1997-11-05
2000-04-04
Harrison, Robert H.
Drug, bio-affecting and body treating compositions
Designated organic nonactive ingredient containing other...
Carboxylic acid ester
514946, 514947, 514573, A61K 4714, A61K 4718, A61K 906
Patent
active
060462442
ABSTRACT:
A topical composition of a semi-solid consistency suitable is provided for transdermal application of prostaglandin E.sub.1. The composition comprises prostaglandin E.sub.1, a penetration enhancer, a polysaccharide gum, a lipophilic compound, and an acidic buffer system. The penetration enhancer is an alkyl-2-(N,N-disubstituted amino)-alkanoate ester, an (N,N-disubstituted amino)-alkanol alkanoate, or a mixture of these. The lipophilic compound may be an aliphatic C.sub.1 to C.sub.8 alcohol, an aliphatic C.sub.8 to C.sub.30 ester, or a mixture of these. The composition includes a buffer system capable of providing a buffered pH value for said composition in the range of about 3 to about 7.4.
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Adachi et al. Inhibitory Effect of Prostaglandin E1 on Laurate-Induced Peripheral Vascular Occlusive Sequelae in Rabbits: Optimized Topical Formulation with Beta-Cyclodextrin Derivative And Penetration Enhancer HPE-101. Journal of Pharmaceutical Pharmacology. Dec. 1992. vol. 44, No. 12. pp. 1033-1035.
Article, "Alkyl N,N-Disubstituted-Amino Acetates", Buyuktimkin, N., et al., pp. 91-102, appearing in "Percutaneous Penetration Enhancers," 1995 by CRC Press, Inc.
Buyuktimkin Nadir
Buyuktimkin Servet
Yeager James
Harrison Robert H.
NexMed (Holdings) , Inc.
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