Topical compositions for enhancing sexual responsiveness

Details Topical compositions for enhancing sexual responsiveness Topical compositions for enhancing sexual responsiveness

2007-05-08

2007-05-08

Leith, Patricia (Department: 1655)

Drug, bio-affecting and body treating compositions

Plant material or plant extract of undetermined constitution...

C424S727000

Reexamination Certificate

active

10775574

ABSTRACT:
A topical composition which enhances sexual responsiveness of a mammal is disclosed. An effective dosage of a peripheral vasodilator, an absorption enhancer and, optionally, a vasoconstrictor and an alpha receptor blocker are combined with a pharmaceutically-acceptable topical vehicle to produce the composition. The compositions are applied topically to the penis or labia majora and minora pudenda to enhance erection or vasocongestion.

REFERENCES:
patent: 5208031 (1993-05-01), Kelly
patent: 5217997 (1993-06-01), Levere et al.
patent: 5232935 (1993-08-01), Colaset et al.
patent: 5240945 (1993-08-01), Warshaw
patent: 5318960 (1994-06-01), Toppos
patent: 5428070 (1995-06-01), Cooke
patent: 5451407 (1995-09-01), Cormier et al.
patent: 5496827 (1996-03-01), Patrick
patent: 5543430 (1996-08-01), Kaesemeyer
patent: 5595753 (1997-01-01), Hechtman
patent: 5767160 (1998-06-01), Kaesemeyer
patent: 5891459 (1999-04-01), Cooke et al.
patent: 5895658 (1999-04-01), Fossel
patent: 5922332 (1999-07-01), Fossel
patent: 5985860 (1999-11-01), Toppo
patent: 6007824 (1999-12-01), Duckett et al.
patent: 6117872 (2000-09-01), Maxwell et al.
patent: 6207713 (2001-03-01), Fossel
patent: 6294517 (2001-09-01), Garvey et al.
patent: 6323211 (2001-11-01), Garvey et al.
patent: 6340480 (2002-01-01), Duckett et al.
patent: 6368640 (2002-04-01), Wuh et al.
patent: 6428791 (2002-08-01), Lezdey et al.
patent: 6476037 (2002-11-01), Wallace
patent: 6544563 (2003-04-01), Wuh et al.
patent: 6548087 (2003-04-01), Kent et al.
patent: 6548841 (2003-04-01), Frazier et al.
patent: 6579543 (2003-06-01), McClung
patent: 6646006 (2003-11-01), Cooke et al.
patent: 6803060 (2004-10-01), Reyes
patent: 2002/0151592 (2002-10-01), Cooke et al.
patent: 2002/0165429 (2002-11-01), Thompson
patent: 2002/0183297 (2002-12-01), Niazi
patent: 2002/0187165 (2002-12-01), Harbeck
patent: 2003/0059484 (2003-03-01), Bonte et al.
patent: 2003/0077296 (2003-04-01), Denton et al.
patent: 2004/0102358 (2004-05-01), Scivoletto
patent: 000405067 (1991-02-01), None
patent: 9905262 (2000-04-01), None
Alternate Medicine Network: ViaGirl Women's Pleasure Enhancer, URL <http://web.archive.org/web/20030207090059/www.altmednetwork.net/WomensHealth/viagirl.htm, pp. 1-6.
Burnett A.L., Chang, A.G., Crone, J.K., Huang, P.L., Sezen, S.F., Noncholinergic Penile Erection in Mice lacking the gene for endothelial nitric oxide synthase. J. Andrology 23(1):92-97 (2002).
Cellek S, Moncada S, Nitrergic neurotransmission mediates the non-adrenergic non-cholinergic responses in the clitoral corpus cavernosum of the rabbit. Br. J. Pharmacol. 125(8):1627-9 (1998).
Christianson DW, Arginase: structure, mechanism, and physiological role in male and female sexual arousal. Acc. Chem. Res. 38(3):191-201 (2005).
Elsner, P., Maibach, H.I. Cutaneous response to topical methyl nicotinate in human forearm and vulvar skin. J. Dermatol. Sci. 2(5):341-5 (1991).
Gonzalez-Cadavid NF, Rajfer J, Therapy of erectile dysfunction. Endocrine 23(2-3):167-76 (2004).
Gragasin FS, Michelakis ED, Hogan A, Moudgil R, Hashimoto K, Wu X, Bonnet S, Haromy A, Archer SL, The neurovascular mechanism of clitoral erection: nitric oxide and cGMP-stimulated activation of BKCa channels. FASEB J. 18(12):1382-91 (2004).
Guy, RH, Maibach, HI., Rapid radial transport of methyl nicotinate in the dermis, Archives Dermatol. Res. 273:91-95 (1982).
Irritants, Rubefacients and Vesicants, in Remington's Pharmaceutical Sciences 17th Edition, Mack Publishing Company, Eaton, Pennsylvania, p. 782, (1985).
Ito TY, Trant AS, Polan ML., A double-blind placebo-controlled study of ArginMax, a nutritional supplement for enhancement of female sexual function. J. Sex Martial Ther. 27(5):541-9 (2001).
Kim NN, Christianson DW, Traish AM, Role of arginase in the male and female sexual arousal response. J. Nutr. 134(10 Suppl):2873S-2879S; dicussion 2895S (2004).
Klotz, T. Mathers, M.J. Braun, M., Bloch, W., Englemann, U. Effectiveness of oral L-arginine in first-line treatment of erectile dysfunction in a controlled crossover study. Urol. Int. 63(4):220-23 (1999).
Lebret, T, Herve JM, Gorny P, Worcel M, Botto H., Efficacy and safety of a novel combination of L-arginine glutamate and yohlmbine hydrochloride: a new oral therapy for erectile dysfunction. Eur. Urol. 41(6):608-13; discussion 613 (2002).
McKay, D., Nutrients and botanicals for erectile dysfunction: examining the evidence. Altern. Med. Rev. 9(1):4-16 (2004).
Meston CM, Worcel M, The effects of yohimbine plus L-arginine glutamate on sexual arousal in postmenopausal women with sexual arousal disorder. Arch. Sex Behav. 31(4):323-32 (2002).
Moncada S., Higgs EA. Molecular mechanisms and therapeutic strategies related to nitric oxide. FASEB 9:1319-1330 (1995).
Muller, B., Kasper, M., Surber, C., Imanidis G., Permeation, metabolism and site of action concentration of nicotinic acid derivatives in human skin Correlation with topical pharmacological effect. Eu. J. Pharm. Sci. 20:181-95 (2003).
Park JK, Kim SZ, Kim SH, Kim YG, Cho KW, Renin angiotensin system of rabbit clitoral cavernosum: interaction with nitric oxide. J. Urol. 164(2):556-61 (2000).
Park JK, Kim JU, Lee SO, Hwang PH, Yi HK, Kim YG, Cho KW, Nitric oxide-cyclic GMP signaling pathway in the regulation of rabbit clitoral cavernosum tone. Exp. Biol. Med. 227(11):1022-30 (2002).
Sample of CONNECTION™ packaging including ingredient list, enclosed herewith.
Sivamani RK, Stoeber B, Wu GC, Zhai H, Liepmann D, Maibach H., Clinical microneedle injection of methyl nicotinate: stratum corneum penetration. Skin Res. Technol. 11(2):152-6 (2005).
Stanislavov R, Nikolova V., Treatment of erectile dysfunction with pycnogenol and L-arginine. J. Sex Marital Ther. 29(3):207-13 (2003).
Web page from the Better Business Bureau of Metropolitan New York, Inc., Apr. 21, 2005.
Woolfson AD, Malcolm RK, Campbell K, Jones DS, Russell JA., Rheological, mechanical and membrane penetration properties of novel dual drug systems for percutaneous delivery. J Control Release. 3;67(2-3):395-408 (2000).

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