Topical compositions for enhancing glutathione production

Details Topical compositions for enhancing glutathione production Topical compositions for enhancing glutathione production

1998-11-05

2000-11-21

Dodson, Shelley A.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Cosmetic, antiperspirant, dentifrice

514 18, 514562, 514563, 514706, 514844, A61K 700, A61K 3800, A61K 31195, A61K 31095

Patent

active

061499250

ABSTRACT:
The invention provides cosmetic or pharmaceutical compositions for topical application to the skin comprising glutathione-enhancing effective amounts of a glycine compound, a glutamine compound, and a sulfhydryl-containing organic acid, in a cosmetically or pharmaceutically acceptable carrier. The compositions are useful in increasing glutathione synthesis in skin cells, and in treating skin conditions associated with glutathione depletion in skin cells.

REFERENCES:
patent: 4710489 (1987-12-01), Meister
patent: 5248697 (1993-09-01), Wilmore
patent: 5296500 (1994-03-01), Hillebrand
patent: 5709868 (1998-01-01), Perricone
Correlation Between Endogenous Glutathione Content and Sensitivity of Cultured Human Skin Cells To Radiation At Defined Wavelengths in the Solar Ultraviolet Range, R. M. Tyrrell and M. Pidoux, Photochemistry and Photobiology, vol. 47, No. 3, pp. 405-412, 1988.
Alton Meister, Glutathione Metabolism and its Selective Modification, The Journal of Biological Chemistry,vol. 263, No. 33, Issue of Nov. 25, pp. 17205-17208, 1988.
Alton Meister, Selective Modification of Glutathione Metabolism, Science, vol. 220, Apr. 1983, pp. 471-477.

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