Topical compositions containing selenoamino acids for the preven

Details Topical compositions containing selenoamino acids for the preven Topical compositions containing selenoamino acids for the preven

1987-04-29

1989-09-12

Ore, Dale R.

Drug, bio-affecting and body treating compositions

Topical sun or radiation screening, or tanning preparations

514937, 514938, A61K 740, A61K 742

Patent

active

048658405

ABSTRACT:
Topical application of selenoamino acids, such as L-selenomethionine, leads to significantly enhanced levels of selenium in the skin, and also to enhanced levels of selenium in the plasma and liver without toxicity. These enhanced levels of selenium provide protection from ultraviolet radiation-induced skin damage, and significantly reduce the incidence of skin cancers following ultraviolet light exposure.

REFERENCES:
The New England Journal of Medicine, vol. 264, SELENIUM SULFIDE INTOXICATION, Captain James W. Ransone et al., 2/23/61, 384-385.
J. Invest Dermatol, vol. 24, TOXICITY-STUDIES ON SELENIUM DISULFIDE SUSPENSION, Edward M. Shapiro, M.D. et al., (1955), 423-428.
Southern Medical J., vol. 55, EFFECT OF SELENIUM DISULFIDE ON RABBIT EYES, J. William Rosenthal et al., 1962, p. 318.
J. American Medical Association, vol. 156, USE OF SELENIUM SULFIDE SHAMPOO IN SEBORRHEIC DERMATITIS, Eugene S. Bereston, M.D., 1246-1247.
J. of Investigative Dermatology, LACK OF TOXICITY OF SELENIUM SULFIDE SUSPENSION FOR HAIR ROOTS, H. C. Maguire, Jr. et al., 8/4/62, 469-470.
Acta. path. microbiol. immunol. scand. Sect. A, vol. 91, BRIEF REPORT ORAL SELENIUM INHIBITS SKIN REACTIONS TO UV LIGHT IN HAIRLESS MICE, E. B. Thorling et al., 1983, 81-83.
Cancer Letters, vol. 27, SELENIUM INHIBITS UV-LIGHT-INDUCED SKIN CARCINOGENESIS IN HAIRLESS MICE, K. Overvad et al., 1985, 163-170.
Newsline, NUTRITIONAL SUPPLEMENTS OF SELENIUM TESTED FOR CANCER PREVENTION.
Nutrition and Cancer, PLASMA SELENIUM AND SKIN NEOPLASMS: A CASE-CONTROL STUDY, L. C. Clark et al., 1984, 13-21, vol. 6, No. 1.
Chem. Abst., 1970, vol. 80, p. 119314x, Passwater.
Chem. Abs., 1973, vol. 84, p. 31387v, Tamba.
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