Topical compositions containing copper (II) complexes of 3,5-dio

Details Topical compositions containing copper (II) complexes of 3,5-dio Topical compositions containing copper (II) complexes of 3,5-dio

1982-05-05

1985-09-03

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

548101, 548105, A61K 3130, A61K 31415, C07F 108

Patent

active

045392064

ABSTRACT:
Novel copper (II) coordination complexes of 3,5-dioxo-pyrazolidine derivatives with dimethylsulphoxide, dimethylformamide, and 1,4-dioxan coordination ligands are described. The complexes are potent anti-inflammatory agents and are usually applied topically in non-aqueous solution, showing good dermal penetration and systemic absorption.

REFERENCES:
patent: 3389050 (1968-06-01), Dulin et al.
patent: 4008200 (1977-02-01), Avar et al.
patent: 4053621 (1977-10-01), Moller et al.
patent: 4207317 (1980-06-01), Walker
patent: 4221785 (1980-09-01), Sorenson
Sorenson, J. Med. Chem., vol. 19, No. 1, pp. 135-148 (1976).

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