Topical compositions and methods for treatment of skin damage an

Details Topical compositions and methods for treatment of skin damage an Topical compositions and methods for treatment of skin damage an

1995-09-07

1997-07-01

Venkat, Jyothsna

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Cosmetic, antiperspirant, dentifrice

514944, 424DIG5, A61K 748

Patent

active

056435860

ABSTRACT:
Compositions for the topical treatment of sagging subcutaneous muscle and overlying cutaneous tissue contain catecholamines and/or related compounds in a dermatologically acceptable carrier. Examplary catecholamines include adrenaline, norepinepherine, dopamine and their precursors; catecholamine precursors such as tyrosine and phenylalanine are preferred. Preferred embodiments further contain at least one other ingredient that enhances neurotransmitter synthesis and/or skin penetration. In some embodiments, an acetylcholine precursor such as dimethylaminoethanol and/or a fatty acid ester of ascorbic acid are included in the formulation. In these and other embodiments, particularly those employing tyrosine and/or phenylalanine as a catecholamine precursor, other cofactors such as vitamin B.sub.6 and pantothenic acid or calcium pantothenate are included in the composition to enhance the action of the active ingredients. Other compounds that scavenge free radicals and antioxidants may also be added.

REFERENCES:
patent: 4647453 (1987-03-01), Meisner
patent: 4772591 (1988-09-01), Meisner
patent: 4938969 (1990-07-01), Schinitsky et al.

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