Topical composition for treatment of blepharitis

Details Topical composition for treatment of blepharitis Topical composition for treatment of blepharitis

1995-06-07

1997-03-25

Spivack, Phyllis G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

5142355, A61K 31415, A61K 31535

Patent

active

056145454

ABSTRACT:
A pharmaceutical composition for treating blepharitis or blepharoconjunctivitis is disclosed for topical administration comprising a nitroimidazole, as metronidazole, in a suitable ophthalmic carrier to be applied directly to affected ocular tissues. The carrier may be an artificial tear solution, an ointment, a water soluble gel, a nonaqueous carrier or an eyelash shampoo.

REFERENCES:
patent: 4612193 (1986-09-01), Gordon et al.
Bleicher, et al., "Topical metronidazole therapy for rosacea," Arch. Dermatol. 123: 609-614 (1987).
Browning, et al., "Ocular Rosacea" Survey of Ophthalmol. 31: 145-158 (1986).
Mattila, et al., "Penetration of metronidazole and trindazole into the aqueous humor in man" Chemotherapy 29: 188-191 (1983).

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