Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Cosmetic – antiperspirant – dentifrice
Reexamination Certificate
2002-05-30
2003-08-19
Dodson, Shelley A. (Department: 1616)
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Cosmetic, antiperspirant, dentifrice
C424S047000, C424S059000, C424S061000, C424S063000, C424S064000, C424S400000, C514S710000
Reexamination Certificate
active
06607737
ABSTRACT:
FIELD OF INVENTION
The present invention relates to cosmetic compositions suitable for use on mammalian skin. These compositions comprise a bonding agent capable of attaching a cosmetic benefit agent to mammalian skin. In particular, the bonding agent is activated, trans-structured and is linked to the cosmetic benefit agents that are then in turn linked directly or indirectly to the skin.
BACKGROUND
It is well known in the skin beauty care field that cosmetic benefit agents may be topically applied to human skin. There are a number of benefit agents that can be applied to the skin for varying purposes including moisturizers, humectants, color cosmetics, etc. There is, however, a common problem that arises in each of these areas of beauty care. The problem is the failure of the above-mentioned cosmetic benefit agents to remain substantively attached to the skin to which they are applied. That is, the benefit agents that are applied fail to “stick” to the skin such that a long-wear result is achieved to any noticeable extent.
The present invention seeks to solve this substantivity deficiency that is typical in topically applied products by utilizing a chemical hook based technology. The operative chemical hook of the present invention is a bonding agent that serves as a gluing mechanism between a cosmetic benefit agent of interest and one or more protein molecules that are found in the skin and/or hair. In particular, Applicants have found that activating certain molecules then allows them to serve as suitable bonding agents such that improved substantivity of various benefit agents are observed on the skin. Additionally, Applicants have found that, due to the selective reactivity of the bonding agents with the proteins in the skin, an unexpected evenness of coverage benefit is also imparted by the use of the claimed compositions. That is, undesirable caking or build-up of a benefit agent does not result since substantivity only occurs at the reactive sites between the bonding agents and proteins found in the substrate.
Without being limited by theory, the chemical hook bonding agents covalently bond to certain amino acids present in proteinaceous substrates like skin, cuticles, and hair to form a substantive attachment of the desired cosmetic benefit agent to the substrate as demonstrated by the chemical reaction that follows
wherein AA represents functional amino acids containing amino, sulfhydryl, carboxyl, or hydroxyl groups and wherein X, L, and R are defined below.
SUMMARY OF THE INVENTION
The present invention relates to cosmetic compositions that comprise a safe and effective amount of a bonding agent comprising the following trans structure
wherein X represents a cosmetic benefit agent, L represents an optional chemical linker between X and the remainder of the bonding agent; and R represents an activating, electron withdrawing group; and a cosmetically acceptable carrier for the bonding agent wherein the composition is administered topically to mammalian proteinaceous substrates and wherein the bonding agent reacts with a protein contained in the substrate such that the bonding agent, and thus the cosmetic benefit agent, is covalently attached to the substrate, in particular, proteins and other reactive components of the skin. The invention further relates to methods of using the compositions described above as well as various products that include the claimed compositions.
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McBroom, C.R., “Carbohydrate Antigens: Coupling of Carbohydrates to Proteins by Diazonium and Phenylisothiocyanate Reactions”, Methods in Enzymology—IIVII—Complex Carbohhydrates—Part B—Ed. Ginsburg, V., pp. 212-222 (1972).
Bekele Haimanot
Morrissey Christopher Todd
Motley Curtis Bobby
Clark Karen F.
Dodson Shelley A.
Kendall Dara M.
Rosnell Tara M.
The Procter & Gamble & Company
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