Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Cosmetic – antiperspirant – dentifrice
Reexamination Certificate
2002-05-30
2003-09-02
Dodson, Shelley A. (Department: 1616)
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Cosmetic, antiperspirant, dentifrice
C424S047000, C424S059000, C424S061000, C424S063000, C424S064000, C514S063000
Reexamination Certificate
active
06613341
ABSTRACT:
FIELD OF INVENTION
The present invention relates to cosmetic compositions suitable for use on mammalian skin. These compositions comprise a bonding agent capable of attaching a cosmetic benefit agent to mammalian skin. In particular, the bonding agent is linked to the cosmetic benefit agents that are then in turn linked directly or indirectly to the skin.
BACKGROUND
It is well known in the skin beauty care field that cosmetic benefit agents may be topically applied to human skin. There are a number of benefit agents that can be applied to the skin for varying purposes including moisturizers, humectants, color cosmetics, etc. There is, however, a common problem that arises in each of these areas of beauty care. The problem is the failure of the above-mentioned cosmetic benefit agents to remain substantively attached to the skin to which they are applied. That is, the benefit agents that are applied fail to “stick” to the skin such that a long-wear result is achieved to any noticeable extent.
The present invention seeks to solve this substantivity deficiency that is typical in topically applied products by utilizing a chemical hook based technology. The operative chemical hook of the present invention is a bonding agent that serves as a gluing mechanism between a cosmetic benefit agent of interest and one or more protein molecules that are found in the skin and/or hair. In particular, Applicants have found that activating certain molecules then allows them to serve as suitable bonding agents such that improved substantivity of various benefit agents are observed on the skin. Additionally, Applicants have found that, due to the selective reactivity of the bonding agents with the proteins in the skin, an unexpected evenness of coverage benefit is also imparted by the use of the claimed compositions. That is, undesirable caking or build-up of a benefit agent does not result since substantivity only occurs at the reactive sites between the bonding agents and proteins found in the substrate.
Without being limited by theory, the chemical hook bonding agents covalently bond to certain amino acids present in proteinaceous substrates like skin, cuticles, and hair to form a substantive attachment of the desired cosmetic benefit agent to the substrate as demonstrated by the chemical reaction that follows
wherein AA represents functional amino acids containing amino, sulfhydryl, carboxyl, or hydroxyl groups and wherein X, L, and R are defined below.
SUMMARY OF THE INVENTION
The present invention relates to cosmetic compositions that comprise a safe and effective amount of a bonding agent comprising structure
wherein X represents a cosmetic benefit agent; L represents an optional chemical linker between X and the remainder of the bonding agent; and R represents a hydrocarbon chain that optionally contains heteroatoms; and a cosmetically acceptable carrier for the bonding agent wherein the composition is administered topically to a mammalian proteinaceous substrate and wherein the bonding agent reacts with a protein contained in the substrate such that the bonding agent is covalently attached to the substrate, in particular, proteins and other reactive components of the skin. The invention further relates to methods of using the compositions described above as well as various products that include the claimed compositions.
DETAILED DESCRIPTION OF THE INVENTION
The present invention relates to topical compositions capable of delivering substantively attached cosmetic benefit agents to mammalian skin. The essential components of these compositions are described below. Also included is a nonexclusive description of various optional and preferred components useful in embodiments of the present invention.
As used herein, “safe and effective amount” means an amount of a compound, component, or composition (as applicable) sufficient to significantly induce a positive effect (e.g., confer a noticeable cosmetic benefit), but low enough to avoid serious side effects, (e.g., undue toxicity or allergic reaction), i.e., to provide a reasonable benefit to risk ratio, within the scope of sound medical judgment.
As used herein, “cosmetic benefit agent” means a compound, material, and/or active that confers an aesthetic feature to the substrate to which it is applied, which is preferably skin.
As used herein, “chemical linker” refers to a hydrocarbon chain, optionally containing heteroatoms, e.g., S, N, Se, O, substituted or unsubstituted aryls, Si, SiO, siloxane “D” groups [{(CH
3
)}—Si—O
3
], siloxane “M” groups [{(CH
3
)
3
}—Si—O], siloxane “T” groups [{(CH
3
)}—Si—O
3/2
], esters thiol esters, amides, and selenium esters, that form a covalent bond between the cosmetic benefit agent and the bonding agent such that a “chemical hook” is formed.
The present invention can comprise, consist of, or consist essentially of any of the required or optional ingredients and/or limitations described herein.
All percentages and ratios are calculated on a weight basis unless otherwise indicated. All percentages are calculated based upon the total composition unless otherwise indicated.
All molar weights are weight average molecular weights and are given in units of grams per mole.
All ingredient levels are exclusive of solvents, by-products, or other impurities that may be present in commercially available sources, unless otherwise indicated.
All measurements made are at ambient room temperature, which is approximately 73° F., unless otherwise designated.
All documents referred to herein, including patents, patent applications, and printed publications, are hereby incorporated by reference in their entirety in this disclosure.
Bonding Agent
The compositions of the present invention comprise a bonding agent comprising structure
wherein X represents a cosmetic benefit agent; L represents an optional chemical linker between X and the remainder of the bonding agent; and R represents a hydrocarbon chain that optionally contains heteroatoms.
A particular embodiment of the present invention includes a composition comprising a bonding agent comprising the following structure
wherein X represents a cosmetic benefit agent, L and L′ represent optional chemical linkers between X and a remainder of the bonding agent; and R represents a hydrocarbon chain that optionally contains heteroatoms. In each of these embodiments, it is conceivable that multiple chemical hook entities may extend from one or more of the cosmetic benefit agents that are contained in the core of the bonding agent. Moreover, multiple cosmetic benefit agents may be attached to the bonding agent of the present invention. For instance, a bonding agent may be attached to or include a vitamin, a sunscreen active, an antioxidant, and others, in combination.
More preferably, R is an alkyl selected from the group consisting of a methyl, ethyl, propyl, butyl, and combinations thereof.
Suitable chemical linkers, L and L′, include, but are not limited to, hydrocarbon chains containing heteroatoms like S, N, Se, O, substituted or unsubstituted aryls, Si, SiO, siloxane “D” groups [{(CH
3
)}—Si—O
3
], siloxane “M” groups [{(CH
3
)
3
}—Si—O], siloxane “T” groups [{(CH
3
)}—Si—O
3/2
], etc.
Without being limited by theory, Applicant believes that the bonding agent may exist in trans or cis conformation but that trans is preferred.
The cosmetic benefit agent of the present invention is suitable for providing therapeutic or aesthetic skin benefits by deposition and consequent adhesion to skin. Suitable cosmetic agents include, but are not limited to those selected from the group consisting of absorbents, anti-acne actives, anti-caking agents, anti-cellulite agents, anti-foaming agents, anti-fungal actives, anti-inflammatory actives, anti-microbial actives, anti-oxidants, antiperspirant/deodorant actives, anti-skin atrophy actives, anti-viral agents, anti-wrinkle actives, artificial tanning agents and accelerators, astringents, barrier repair agents
Bekele Haimanot
Morrissey Christopher Todd
Motley Curtis Bobby
Clark Karen F.
Dodson Shelley A.
Kendall Dara M.
Rosnell Tara M.
The Procter & Gamble & Company
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