Topical composition and method for enhancing lipid barrier synth

Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Cosmetic – antiperspirant – dentifrice

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424 59, 424 63, 424400, 514174, 514461, A61K 908

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active

058558977

ABSTRACT:
The present invention relates to topical compositions useful in enhancing lipid synthesis in skin comprising an effective amount of cafestol, in combination with a pharmaceutically or cosmetically acceptable carrier. Such compositions are useful in treatment or prevention of dry skin and conditions in which the skin's lipid barrier is defective or damaged.

REFERENCES:
patent: 4793990 (1988-12-01), Grollier et al.
Miller et al., Kahweol and Cafestol: Inhibitors of Hamster Buccal Pouch Carcinogenesis, Nutrition and Cancer 15: 41-46, 1991.
Hugget et al, Chemoprotective Effects of Coffee and its Components Cafestol and Kahweol: Effects Xenobiotic Metabolizing Enzymes, Colloq. Sci. Int. Cafe (C.R.) 16(1): 65-72, 1995.
Urgert et al., Effects of Cafestol and Kahweol from Coffee Grounds on Serum Lipids and Serum Liver Enzymes in Humans, Am. J. Clin. Nutr. 61: 149-154, 1995.
Melnick et al., J. Invest. Dermoatol 92:231-234, 1989.

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