Topical composition and method containing deoxy and halo derivat

Details Topical composition and method containing deoxy and halo derivat Topical composition and method containing deoxy and halo derivat

1992-07-01

1994-08-23

Ore, Dale R.

Drug, bio-affecting and body treating compositions

Topical sun or radiation screening, or tanning preparations

424DIG5, 424 47, 424 60, 424 63, 424401, 514847, 514873, 514938, 514944, 514946, 514969, A61K 742, A61K 744, A61K 910, A61K 912

Patent

active

053405684

ABSTRACT:
The subject invention relates to compositions and methods for regulating wrinkles in mammalian skin by topical application of a 2-deoxy- or 2-deoxy-2-halo-lysophosphatidic acid compound having the structure: ##STR1## or a pharmaceutically acceptable salt thereof, wherein --R is unsubstituted or substituted, saturated or unsaturated, straight or branched chain alkyl having from 11 to about 23 carbon atoms; each --X-- is independently --0-- or --S--; --Y-- is --0-- or --CH.sub.2 --; and Z is --H or halo.

REFERENCES:
patent: 4104403 (1978-08-01), Barker et al.
patent: 5238965 (1993-08-01), Piazza et al.
Van Corven, E. J., A. Groenink, K. Jalink, T. Eichholtz & W. H. Moolenaar, "Lysophosphatidate-Induced Cell Proliferation: Identification and Dissection of Signaling Pathways Mediated by G Proteins", Cell, vol. 59 (Oct. 6, 1989), pp. 45-54.
Moolenaar, W. H. & E. J. van Corven, "Growth Factor-Like Action of Lysophosphatidic Acid: Mitogenic Signalling Mediated by G Proteins", 1990 Protooncogenes in Cell Development, Wiley, Chichester (Ciba Foundation Symposium 150) pp. 99-111.
Brachwitz, H. & P. Langen, "Synthesis and Cytostatic Properties of Halo Analogs of Phospholipids", IUPAC Int. Sym. Chem. Nat. Prod., vol. 2 (1978), pp. 227-230.
Hara, I. & H. Kaneko, "Synthesis of Trimethylene Glycol Lipids. I. Phopholipid Synthesis Without Nitrogen Bases", Bull. Soc. Chim. Biol., vol. 46 (1964), pp. 339-351 (abstract only: Chemical Abstracts, vol. 62 (1965), pp. 3920-3921).

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