Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Recombinant or stably-transformed bacterium encoding one or...
Patent
1978-08-16
1981-03-03
Schenkman, Leonard
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Recombinant or stably-transformed bacterium encoding one or...
424311, 424317, 424318, 424331, 424337, 424339, 424343, A61K 3122, A61K 31215
Patent
active
042541450
ABSTRACT:
Pharmaceutical compositions useful as vasodilators whose activity may be restricted to the site of application by control of the dose applied which comprises a prostaglandin selected from the group consisting of the natural and synthetic analogs of the PGE, PGA and PGE.sub..beta. types in a pharmaceutical carrier. The compositions are applied topically and by local injection to increase peripheral circulation, or to treat peripheral vascular disorders of the arteriospastic and occlusive types. The prostaglandins and pharmaceutical compositions containing them disclosed herein are also administered topically and by local injection to lower the systemic blood pressure of man and warm blooded animals. Systemic action is obtained by the use of an effective dosage greater than that used to induce localized action at the site of application.
REFERENCES:
patent: 3551554 (1968-08-01), Herschler
patent: 4061670 (1976-07-01), Floyd et al.
patent: 4078083 (1978-03-01), Babej et al.
patent: 4080506 (1978-03-01), Morozowich
patent: 4094899 (1978-06-01), Hess
patent: 4103026 (1978-07-01), Carlson
Williams et al., Chemical Abstracts 88:183486x (1978).
American Cyanamid Company
Hammond Richard J.
Schenkman Leonard
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