Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1997-06-13
1998-11-10
Schenkman, Leonard
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514859, 514864, 514887, A61K 3144
Patent
active
058344802
ABSTRACT:
Treatment of acne through topical administration is an aspect of the present invention. Specifically, opioids may be applied in any therapeutically acceptable carrier including gels, creams, lotions, and sprays. Therapeutic effects observed with the present invention include decrease in redness, swelling, and inflammation. Treatment of other inflammatory conditions is also disclosed. Treatment of suitable conditions in accordance with the present invention results in significant improvements in healing of those conditions.
REFERENCES:
patent: 4416886 (1983-11-01), Bernstein
patent: 5589480 (1996-12-01), Elkhoury et al.
Bergfeld, W.F. "The evaluation and management of acne: Economic Considerations," J. Am.Acad. Dermatol., vol. 32, pp. S52-S56.
Berson, D.S. and Shalita, A.R. "The treatment of acne: The role of combination therapies," J. Am. Acad. Dermatol., vol. 32, pp. S31-S41.
Dickenson, "Neurophysiology of Opioid Poorly Responsive Pain," Cancer Surveys, vol. 21: Palliative Medicine: Problem Areas in Pain and Symptom Management.
Kaminer, M.S. and Gilchrist, B.A., "The many faces of acne," J. Am.Acad. Dermatol, vol. 32, pp. S6-S14, May.
Kinnman, et al., "Peripherally Administered Morphine Attenuates Capsaicin-Induced Mechanical Hypersensitivity in Humans," Anesth Analg, pp. 595-599.
Koo, J., "The psychosocial impact of acne: Patients' perceptions," J. AM. Acad. Dermatol., vol. 32, pp. S31-S41, May.
Giardina et al., "Central and Peripheral Analgesic Agents: Chemical Strategies for Limiting Brain Penetration in Kappa-Opioid Agonists Belonging to Different Chemical Classes," I1 Farmaco, pp. 405-418.
Herz, "Role of Immune Processes in Peripheral Opioid Analgesia," in The Brain Immune Axis and Substance Abuse, Plenum Press, New York, pp. 193-199.
Makman, "Morphine Receptors in Immunocytes and Neurons," Advances in Neuroimmunology, vol. 4, pp. 69-82.
Mather,"Opioids: A Pharmacologist's Delight|" Australasian Society of Clinical Experimental Pharmacologists and Toxicologists Symposium, 1994, Clinical and Experimental Pharmacology and Physiology, pp. 833-836.
Needham,"Painless Lumbar Surgery:Morphine Nerve Paste," Connecticut Medicine,vol. 60, No. 3, pp. 141-143.
Nguyen, Q.H. et al., "Management of Acne Vulgaris," American Family Physician, vol. 50, No. 1, pp. 89-96.
Peyman et al., "Effects of morphine on corneal sensitivity and epithelial wound healing: implications for topical ophthalmic analgesia," British Journal of Opthamology, pp. 138-141, Feb.
Sharp et al.,eds., The Brain Immune Axis and Substance Abuse, Chap. 27, Plenum Press, New York.
Siddall and Cousins, "Pain Mechanisms and Management : an Update," Clinical Experimental Pharmacology and Physiology, pp. 679-688.
Solomon, B.A., and Shalita, A.R., "Effects of Detergents on Acne," Clinics in Dermatology, vol. 14, pp. 96-98.
Stein et al., "Antiociceptive effects of mu-and kappa-agonists in inflammation are enhanced by a peripheral opioid receptor-specific mechanism of action," Eur.J. Pharmacol., pp. 255-264.
Stein et al., "No Tolerance to Peripheral Morphine Analgesia in Presence of Opioid Expression in Inflamed Synovia," J. Clin. Invest., vol. 98, No. 3, pp. 793-799, Aug.
Stein et al., "Opioids as novel intra-articular agents in arthritis," Progess in Pain Research and Management, Fields,H.L. and Liebeskind, J.C., eds., IASP Press, Seattle, pp. 289-296.
Stein et al., "Peripheral effect of fentanyl upon nociception in inflamed tissue of the rat," Neurosci. Lett., pp. 225-228.
Sykes, N.L. Jr. and Webster, G.F., "Acne: A Review of Optimum Treatment," Drugs, vol. 48, No. 1, pp.59-70, 1994.
Traynor, "Opioid Receptors and Their Subtypes: Focus on Peripheral Isolated Tissue Perparations," Neurochem, Int, vol. 24., No. 5, pp. 427-432.
"Acne in Teens: Ways to Control It" a handout adapted from brochure in AAFP Patient Education Brochure Series, Health Notes from Your Family Doctor, Jul.
Chemical Abstracts vol. 124: 3777g MacLean (U.K.application2,287,404; 1995), 1996.
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