Topical application of opioid analgesic drugs such as morphine

Drug – bio-affecting and body treating compositions – Effervescent or pressurized fluid containing – Organic pressurized fluid

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424484, 424485, 424486, 424487, 424488, 424 43, 514282, 514812, 514944, 514946, 514947, 514969, A61K 912, A61K 906, A61K 31485

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active

061432784

ABSTRACT:
The invention is directed to methods and pharmaceutical compositions for the topical administration of opioid analgesic drugs such as morphine. In particular, the invention relates to topical administration of an opioid analgesic agent, e.g., morphine sulfate, in admixture with a skin- or mucosal-specific penetration enhancer, to produce a localized analgesic effect in inflamed or non-inflamed skin or mucosal tissue, and without a transdermal or transmucosal migration of opioid agent, e.g., into the systemic circulation.

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