Topical application of opioid analgesic drugs such as morphine

Details Topical application of opioid analgesic drugs such as morphine Topical application of opioid analgesic drugs such as morphine

1994-08-17

1996-12-31

Dodson, Shelley A.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

424DIG13, 514817, 514946, 514947, 514969, A61K 31485

Patent

active

055894801

ABSTRACT:
The present invention is directed to a method and apparatus for the topical application of opioid analgesic drugs such as morphine. Specifically, the present invention relates to a topical application of the opioid drug and specifically a morphine sulphate in a diluted solution to produce an analgesic effect in a localized area and typically in a localized inflamed area and without a transdermal migration of the opioid drug into the blood stream.

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Tennant et al, Abs. of Int. Pharm. Abs. (Lancet) v. 342 (Oct. 23, 1993) p. 1047-1048.
J. L. Joris et al., Anaesth. Analg., Opioid Analgesia At Perhipheral Sites: A Target for Opioids Released During Stress and Inflammation? 66:1277-81 (1987).

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