Topical application of muscarinic agents such as neostigmine for

Details Topical application of muscarinic agents such as neostigmine for Topical application of muscarinic agents such as neostigmine for

1998-11-09

1999-11-30

MacMillan, Keith D.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Phosphorus containing other than solely as part of an...

514123, 514859, 514855, 514289, 514912, 514 7804, 424401, A01N 5700

Patent

active

059943300

ABSTRACT:
Treatment of acne through topical administration is an aspect of the present invention. Specifically, muscarinic agents may be applied in any therapeutically acceptable carrier including gels, creams, lotions, and sprays. Therapeutic effects observed with the present invention include decrease in redness, swelling, and inflammation. Treatment of other inflammatory conditions is also disclosed. Treatment of suitable conditions in accordance with the present invention results in significant improvements in healing of those conditions.

REFERENCES:
patent: 3275510 (1966-09-01), Magid et al.
patent: 4416886 (1983-11-01), Bernstein
patent: 4626539 (1986-12-01), Aungst et al.
patent: 4871750 (1989-10-01), Roberts
patent: 4897260 (1990-01-01), Ross et al.
patent: 5069909 (1991-12-01), Sharma et al.
patent: 5540918 (1996-07-01), Castillo et al.
patent: 5834480 (1998-11-01), El Khoury
J. L. Joris et al., Anesth. Analg., Opioid Analgesia At Perhipheral Sites: A Target for Opioids Released During Stress and Inflammation? 66:1277-81 (1987).
H. Bouaziz, MD et al., Anesth Analg., "Postoperative Analgesia from Intrathecal Neostigmine in Sheep," 80:1140-4 (1995).
G. Lauretti, MD et al., Anesth Analg., "Dose-Response Study of Introthecal Morphine Versus Intrathecal Neostigmine, Their Combination . . . " 82:1182-7 (1996).
S. Abram, MD et al., Anesth Analg., "Intrathecal Acetyl Cholinesterase Inhibitors Produce Analgesia That is Synergistic with Morphine and Clonidine in Rats," 81:501-7 (1995).
C. Stein, M.D. et al., New England Journal of Medicine, vol. 325, No. 16 "Analgesic Effect of Intraarticular Morphine After Arthroscopic Knee Surgery," pp. 1123-1126.
T. Yaksh, Ph.D. et al., Anesthesiology, "Studies on the Safety of Chronically Administered Intrathecal Neostigmine Methylsulfate in Rats and Dogs," V 82. No. 2, Feb. 1995.
"Morphine--A `Local Analgesic,`" International Association for the Study of Pain, vol. III.
G. Lauretti, MD et al., Anesth Analg "The Effects of Intrathecal Neostigmine on Somatic and Visceral Pain: Improvement by Associate with a Peripheral Anticholinergic," 81:615-20 (1996).
D. Hood, M.D., et al., Anesthesiology, "Phase I Safety Assessment of Intrathecal Neostigmine Methylsulfate in Humans," V 82., No. 2, Feb. 1995 pp. 331-342.
Goodman & Gillman's, The Pharmacological Basis of Therapeutics, 9th Ed., McGraw-Hill pp. 141-175.
Tennant et al. Abs. of Int. Pharm. Abs. (Lancet) v. 342 (Oct. 23, 1993) p. 1047-1048.
Letters to the Editor, The Lancet, vol. 342, Oct. 23, 1993, pp. 1047-1048.
C. Stein, M.D., "The Control of Pain in peripheral Tissue by Opioids," Mechanisms of Disease, vol. 332, No. 25, pp. 1685-1690, (1995).
C. Williams, Intrasite Gel: A Hyrogel Dressing, Product Focus (3-page article).
Remington Pharmaceutical Sciences 18th ed., Chapter 87, "Medicated Applications," pp. 1596-1614 (1990).
C. Stein, "Peripheral and Non-Neuronal Opioid Effects," Current Scient Ltd., 1-85922-136-X ISSN 0952-7907, pp. 347-351.
S. Moiniche, et al., "Peripheral Antinociceptive Effects of Morphine After Burn Injury," Acta Anaesthesiologica Scandinavica, ISSN 0001-51772, pp. 710-712 (1993).
C. Stein, "Peripheral Mechanisms of Opioid Analgesia," Anesth Analg 1993; 76:182-92.
C. Stein et al., "Peripheral Opioid Receptors," Annals of Medicine 17:219-221 (1995).

Affiliated with

Also associated with

Rating

Topical application of muscarinic agents such as neostigmine for does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Topical application of muscarinic agents such as neostigmine for, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Topical application of muscarinic agents such as neostigmine for will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1672736