Drug – bio-affecting and body treating compositions – Topical body preparation containing solid synthetic organic...
Patent
1993-02-01
2000-04-04
Criares, Theodore J.
Drug, bio-affecting and body treating compositions
Topical body preparation containing solid synthetic organic...
424811, 424 7807, 4241341, 4241501, 4241581, 514841, 514843, A61K 3174, A61K 39395, A61K 3900, A61K 3940
Patent
active
060457864
ABSTRACT:
Certain antibody molecules are so stable and so potent at immobilizing sperm as well as the pathogens for sexually transmitted diseases (STDs) that they make possible new prophylactic contraceptive methods: (a) for men, a skin lotion containing antibodies against sperm and against STD pathogens to be applied to the penis and external genitals during sexual activity, thereby delivering prophylactically effective doses of antibodies to virtually all areas of skin and epithelia across which most STDs, including AIDS, are usually transmitted, and, during vaginal intercourse, the penis will deliver a contraceptively reliable dose of the antibodies to the cervical region of the vagina; and (b) for women, intrauterine devices (IUDs) and intravaginal devices (IVDs) that release antibodies into the uterus or into the vagina to provide continuous protection against pregnancy and STDs for periods of months to years.
REFERENCES:
patent: 4652448 (1987-03-01), Sadowski
patent: 4731245 (1988-03-01), Tsurumizu et al.
patent: 4732763 (1988-03-01), Beck et al.
Touchette, N. (1991 AIDS research and mucosal immune studies begin to gel. J. NIH Rep. 3:65-70.
Forrest, B.D. (1991) Women, HIV and mucosal immunity. Lancet 337:835-836.
Nowak, R. (1991) AIDS vaccines: key questions still unanswered. J. NIH Res. 3:37-39.
Sabin, A. (1991) Effectiveness of AIDS Vaccines. Science 251:1161.
Isojima, S. et al. (1987) Establishment and characterization of a human hybridoma secreting monoclonal antibody with high titers of sperm immobilizing and agglutinating activities against human seminal plasma. J. Reprod. Immun. 10:67-78.
Isojima, S. (1989) Human sperm antigens corresponding to sperm-immobilizing antibodies in the sera of women with infertility of unknown cause: personal review of our recent studies. Human Reprod. 4:605-612.
Isojima, S. (1990) Sperm and seminal plasm antigens relevant to contraceptive vaccine development. Curr. Opin. Immun. 2:752-756.
Herr, J.C. et al. (1986) Characterization of a monoclonal antibody to a conserved eptitope on human seminal vesicle-specific peptides: a novel probe/marker system for semen identification. Biol. Reprod. 35:773-784.
Menge, A.C. et al. (1987) Characterization of monoclonal antibodies against human sperm antigens by immunoassays including sperm function assays and epitope evaluation. Am. J. Reprod. Immun. Microbio. 13:108-114.
Bandivdekar, A.H. et al. (1987) Antibodies to human seminal plasma inhibin cause sperm agglutination and impairment of cervical mucus penetration and sperm-egg attachment. Adv. Contracept, 3:1-12.
Hekman, A. Rumke P. (1969) The antigens of human seminal plasma (with special reference to lactoferrin as a spermatozoa-coating antigen). In: Proteins or Biological Fluids 16:549-552.
Vuento, M. et al. (1984) Characterization of fibronectin on human spermatozoa. Hoppe-Seyler's Z Physiol. Chem. 365:757-762.
Glander, H.J. et al. (1987) The equatorial fibronectin band (EFB) on human spermatozoa--a diagnostic help for male fertility ?Andrologia 19:456-459.
Goodman, S.A., Young L.G. (1981) Immunological identification of lactoferrin as a shared antigen on radioiodinated human sperm surface and in radioiodinated human seminal plasma. J. Reprod. Immuno. 3:99-108.
Kamada, M. et al. (1991) Identification of IgG and Fc-binding proteins in human seminal plasma and sperm. Arch. 27:1-7.
Abrescia, P. et al., (2985) Identification and preliminary characterization of a sperm-binding protein in normal human semen. J. Reprod. Fert. 73:71-77.
Saji, F. et al. (1986) Further characterization of a human sperm coating antigen (gp12). Am. J. Reprod. Immun. Microbiol. 12:13-16.
Fellous, M. et al. (1976) The expression of human beta.sub.2 -microglobulin on human spermatozoa. Eur. J. Immunol. 6:21-24.
Voglmayr, J.K., Sawyer, R.F. (1986) Surface transformation of ram spermatozoa in uterine, oviduct and cauda epididymal fluids in vitro. J. Reprod. Fert. 78:315-325.
Ceri, H., Westra, Y. (1988) Host binding proteins and bacterial adhesion: ecology and binding model. Biochem. Cell. Biol. 66:541-548.
Quaissi, M.A. (1988) Role of the RGD sequence in parasite adhesion to host cells. Parasit. Today 4:169-173.
Baughn R.E. (1987) Role of fibronectin in the pathogenesis of syphilis. Rev. Infect. Dis. 9:s372-385.
Peterson, K.M. et al. (1983) Treponema pallidum receptor binding proteins interact with fibronectin. J. Exp. Med. 157:1958-1970.
Alderette, J.F., Baseman, J.B. (1979) Surface-associated host proteins on virulent Treponema pallidum. Inf. Immun. 26:1048-1-56.
Baughn, R.E. (1990) Demonstration and immunochemical characterization of natural, autologous anti-idiotypic antibodies throughout the course of experimental syphilis. Inf. Immun. 58:766-773.
Peterson, K.M., Alderete, J.F. (1984) Iron uptake and increased intracellular enzyme activity follow host lactoferrin binding by Trichomonas vaginalis receptors. J. Exp. Med. 160:398-410.
Peterson, K.M., Alderette, J.F. (1984) Selective acquisition of plasma proteins by Trichomonas vaginalis and human lipoproteins as a growth requirement for this species. Mol. Biochem. Parasit. 12:37-48.
Peterson, K.M., Alderete, J.F. (1982) Host plasma proteins on the surface of pathogenic Trichicomonas vaginalis. Inf. Immuno. 37: 755-762.
Levy, J.A. (1988) The transmission of AIDS: the case of the infected cell. JAMA 259:3037-3038.
Meltzer, M.S. et al. (1990) Role of mononuclear phagocytes in the pathogenesis of human immunodeficiency virus infection, Annu. Rev. Immunol. 8:169-194.
Gartner, S. et al. (1986) The role of mononuclear phagocytes in HTLV-III/LAV infection. Science 222:215-219.
Wells, C.L. et al. (1988) Proposed mechanisms for the translocation of intestinal bacteria. Rev. Inf. Dis. 10:958-979.
Frank, U. et al. (1978) Multiplication of herpes simplex virus types 1 and 2 in macrophages of NMR1 and C57/BL mice. Acta Virol. 22:193-202.
Lopez, C., Dudas, G. (1979) Replication of herpes simplex virus type 1 in macrophages from resistant and susceptible mice. Inf. Immun. 23:432-437.
Kuo, C-C. (1978) Cultures of Chlamydia trachomatis in mouse peritoneal macrophages: factors affecting organism growth. Inf. Immun. 20:439-445.
Shafer, W.M., Rest, R.F. (1989) Interactions of gonococci with phagocytic cells. Annu. Rev. Microbiol. 43:121-145.
Toth, A. (1987) The role of spermatozoa in the development of pelvic inflammatory disease in the woman. Adv. Contracept. 3:97-102.
Baccetti B. et al. (1991) HIV particles detected in spermatozoa of patients with AIDS. J. Submicrosc. Cytol. Pathol. 23:339-345.
Hill, A.C. (1991) Mycoplasma spermatophilum, a new species isolated from human spermatozoa and cervix. Int. J. System. Bact. 41:229-233.
Howard, T.L. (1971) Bacterial hitch-hikers. J. Urol. 106:94.
Huang, E-S. et al. (1986) Molecular epidemiology and oncogenicity of human cytomegalovirus. Biochem. Mol. Epi. Cancer 323-344.
Atkinson P.W. et al. (1991) Association of exogenous DNA with cattle and insect spermatozoa in vitro. Mol. Reprod. Devel. 29:1-5.
Brackett, B.G. et al. (1971) Uptake of heterologous genome by mammalian spermatozoa and its transfer of ova through fertilization. Proc. Nat. Acad. Sci. 68:353-357.
Smiley, L., Huang, E-S. (1990) Cytomegalovirus as a sexually transmitted infection. In Holmes K.K., Mardh, P-A, Sparling, P.F., Wiesner, P.J. (eds.) Sexually Transmitted Diseases. McGraw-Hill, New York. pp. 415-423.
Miller, V.E., Scofield, V.L. (1990) Transfer of HIV by semen: role of sperm. In: Alexander, NJ., Gabelmick, H.L.I., Spieler, J.M. (eds.) Heterosexual Transmission of AIDS. Wiley-Liss, New York, pp. 147-154.
Wolner-Hanssen, P., Mardh, P-A (1984) In vitro test of the adherence of chlamydia trachomatis to human spermatozoa. Fert. Steril. 42:102-107.
Benoist, C., Mathis D. (1989) Sperm cells as vectors for transferring DNA into mouse eggs: a breakthrough for immunologists. Immun. Today 10:369.
Taylor-Robinson, D., Manchee, R.J. (1967) Spermadsorption and spermagglutination by mycoplasmas. Nature 215:484-487.
Toth, A. et al. (1982) Evidence for microbial transfer by spermatozoa. Obstet. Gyn. 59:556-559.
Kiessling, A.A. et al. (1987) Sperm-associ
Cone Richard A.
Whaley Kevin J.
Criares Theodore J.
Johns Hopkins University
LandOfFree
Topical application of antibodies for prophylaxis against sexual does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Topical application of antibodies for prophylaxis against sexual, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Topical application of antibodies for prophylaxis against sexual will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-362144