Topical antibacterial preparation

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

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514801, 514886, 514887, 530356, 424 7806, 424 7807, 424520, 424DIG13, A61K 3800, A61K 3817, A61K 3174

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active

055146570

ABSTRACT:
A topical antibacterial preparation for treating infected wounds and for advancing their healing comprises silver sulfadiazine (SSD) and collagen, in which the w/w ratio of collagen to SSD ranges from 4/1 to 200/1. The concentration of the SSD is preferably from 0.5% to 2.5%, advantageously 1%. The collagen is advantageously native collagen, which may be acid soluble or insoluble, or mixtures thereof. The preparation may comprise an inert excipient, e.g. SiO.sub.2, or blood plasma components, peptides, carbohydrates.

REFERENCES:
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patent: 4581028 (1986-04-01), Fox, Jr. et al.
patent: 4599226 (1986-07-01), Fox, Jr. et al.
patent: 4915694 (1990-04-01), Yamamoto et al.
Popovici et al., Chemical Abstracts, vol. 112, p. 415, Ref. No. 164844k, 1990 (Farmacia (Bucharest) 1988, 36(4),207-216).
Zachary et al., Biological Abstracts, vol. 76, Ref. #47459,83 (J. Trauma, 22(10), 1982, 833-836).
Abstract, vol. 112, No. 18, 30 Apr. 1990, Columbus, OH, US: Abstract No. 164844, Iuliana et al. `Studies on Collagen Gels containing silver sulfamethoxydiazine used in Dermatology and Farmacia vol. 36, No. 4, 1988 pp. 207-216.
Minerva Chirurgica vol. 49, No. 5, May 1994, pp. 377-382 The Journal of Trauma, vol. 22 No. 10, Oct. 1982, pp. 833-836.
Popovici et al. Farmacia, vol. 36, nr. 4, pp. 207-217, 1988.

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