Topical anti-inflammatory compositions

Details Topical anti-inflammatory compositions Topical anti-inflammatory compositions

1986-08-14

1987-07-07

Friedman, Stanley J.

Drug, bio-affecting and body treating compositions

Lymphokine

A61K 3178

Patent

active

046786660

ABSTRACT:
A novel formulation of piroxicam for dermatological administration is disclosed. Pharmaceutical compositions containing piroxicam, lower alkanols, water, carboxyvinyl polymer, polyhydric alcohols, alkanolamines and optionally film-forming agents are prepared, said compositions having a pH of from about 6.5 to about 9.0. The novel formulation is characterized by excellent applicability on the skin, skin-permeability and good stability. The novel formulation, which is in gel ointment form, is as effective as orally administered peroxicam and is well suited for topical administration through skin for the treatment of various types of inflammatory conditions.

REFERENCES:
patent: 3591584 (1971-07-01), Lombardino
patent: 4434164 (1984-02-01), Lombardino
P. Schiantarelli et al., "Anti-inflammatory Activity and Bioavailability of Percutaneous Piroxicam", Arzneim-Forsch./Drug Res., 32(I), No. 3, p. 230 (1982).
Chemical Abstracts, vol. 95, p. 103322x (1981).

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