Topical anti-infective ointment containing silver or silver salt

Details Topical anti-infective ointment containing silver or silver salt Topical anti-infective ointment containing silver or silver salt

1989-07-28

1994-12-20

Cintins, Marianne M.

Drug, bio-affecting and body treating compositions

Inorganic active ingredient containing

Heavy metal or compound thereof

514184, 514252, A61K 3338

Patent

active

053744322

ABSTRACT:
Topical compositions for use in the treatment of burns and other infection-prone wounds and of ocular infection are provided. These compositions comprise silver or a silver salt, an antibiotic selected from among aminoglycoside antibiotics and quinolone antibiotics, with the proviso that the antibiotic is not norfloxacin; and a sterile carrier, such as water or an ointment base.

REFERENCES:
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patent: 4404197 (1983-09-01), Fox et al.
patent: 4535078 (1985-08-01), Fox, Jr. et al.
patent: 4563485 (1986-01-01), Fox et al.
patent: 4612337 (1986-09-01), Fox et al.
Avery's Drug Treatment 3rd Ed Williams & Wilkins Baltimore MD.
Holder et al CA:106 #47128u 1987.
Darrell et al., Cornea 5 (4): 205-209 (1986).
Jacobson et al., Antimicrobial Agents and Chemotherapy 32 (12): 1820-1824 (1988).
Tokumaru et al., Res. Commun. Chemical Pathology and Pharmacology 8 (1): 151-158 (1974).
Mohan et al., Brit. J. Ophthamology 72: 192-195 (1988).
Darrell et al., Tr. Am. Opth. Soc. 82: 75-91 (1984).
Mohan et al., Indian J. Med. Res. 85: 572-575 (1987).
Gufic Ltd. Brochure on "SSZ" 1988.
Modak and Fox, "Sulfadiazine Silver-Resistant Pseudomonas in Burns", Arch. Surg., 116:854-857 (Jul., 1981).

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