Topical anesthetic formulation

Details Topical anesthetic formulation Topical anesthetic formulation

2007-09-25

2007-09-25

Kim, Jennifer (Department: 1617)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

C514S536000, C514S537000, C514S626000, C424S449000

Reexamination Certificate

active

10111241

ABSTRACT:
The topical anesthetic formulation of the present invention is typically a solution that preferably includes lidocaine, USP as the active anesthetic ingredient with benzyl alcohol and isopropyl alcohol. This invention deals with problems commonly associated with topical application of local anesthetics such as: slow onset of action; need for occlusion; messiness of creams, ointments or gels; and rapid loss of effect due to rapid systemic dispersion. The invention permits enhanced penetration of the anesthetic and thereby allows for a lesser total dosage of pharmaceutically active ingredient. The use of a lesser total dosage also decreases systemic toxicity.

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Remington's Pharmaceutical Sciences, 17th Edition, 1985. p. 17920.
Williams et al. Benzyl Alcohol Attenuates the Pain of Lidocaine Injections and Prolongs Anesthesia. J. Dermatol Surg Oncol. 1994 vol. 20, pp. 730-733.
Vaida et al. Prolongation of lidocaine spinal anesthesia with phenylephrine. Anesthesia and Analgesia, 1986, vol. 65, No. 7, pp. 781-785.

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