Topical and transdermal delivery system utilizing submicron oil

Details Topical and transdermal delivery system utilizing submicron oil Topical and transdermal delivery system utilizing submicron oil

1998-01-13

2000-09-05

Webman, Edward J.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

424449, 514938, 514939, 514940, 514947, 514975, A61K 9107, A61M 3700

Patent

active

061139211

ABSTRACT:
The present invention relates to a delivery system which includes a bioactive drug or cosmetic substance presented in the form of submicron oil spheres alone, or drugs or cosmetic substances in a combination with the oil spheres in an aqueous suspension or emulsion. Optionally, a skin penetration enhancer may be included in such formulations. Such preparations achieve improved bioavailability and exert larger pharmacological effects than an equivalent dose of the drug or cosmetic formulated in conventional creams, lotions or oleaginous bases.

REFERENCES:
patent: 4529601 (1985-07-01), Broberg et al.
patent: 4613330 (1986-09-01), Michelson
patent: 4647586 (1987-03-01), Mizushima et al.
patent: 4963367 (1990-10-01), Ecanow
patent: 5039527 (1991-08-01), Tabibi et al.
patent: 5059189 (1991-10-01), Ciltaro et al.
patent: 5342625 (1994-08-01), Hauer et al.
L.C. Collins-Gold et al., "Parental Emulsions for Drug Delivery", Advanced Drug Delivery Reviews, 5:189-205 (1990).
R.J. Prankerd et al., "The Use of Oil-in-Water Emulsions as a Vehicle for Parenteral Drug Administration", Journal of Parenteral Science & Technology, 44: No. 3:139-149 (1990).
WPI Derwent Publications Ltd., London, GB; AN 91-099139 & JP-A-03 044 322 (SHISEIDO KK), Feb. 26, 1991.

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