Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form
Patent
1993-03-23
1999-12-21
Venkat, Jyothsna
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
424401, 424450, 424448, 424449, 514 78, 514786, 514817, 514846, 514859, 514863, 514886, 514887, 514938, 514943, A61K 9107
Patent
active
060045663
ABSTRACT:
The present invention relates to a delivery system which includes a bioactive drug or cosmetic substance presented in the form of submicron oil spheres alone, or drugs or cosmetic substances in a combination with the oil spheres in an aqueous suspension or emulsion. Optionally, a skin penetration enhancer may be included in such formulations. Such preparations achieve improved bioavailability and exert larger pharmacological effects than an equivalent dose of the drug or cosmetic formulated in conventional creams, lotions or oleaginous bases.
REFERENCES:
patent: 4529601 (1985-07-01), Broberg et al.
patent: 4613330 (1986-09-01), Michelson
patent: 4647586 (1987-03-01), Mizushima et al.
patent: 4963367 (1990-10-01), Ecanow
L.C. Collins-Gold et al., "Parental Emulsions for Drug Delivery", Advanced Drug Delivery Reviews, 5:189-208 (19990).
R.J. Frankerd et al., "The Use of Oil-In-Water Emulsions as a Vehicle for Parental Drug Administration", Journal of Parental Science and Technology, 44 No. 3:139-149 (1990).
Aviv Haim
Friedman Doron
Schwartz Joseph
Pharmos Corp.
Venkat Jyothsna
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