Topical .alpha.-1-antitrypsin, non-aqueous lipid miscible, benza

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

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514647, A61K 3710, A61K 31135

Patent

active

053468864

ABSTRACT:
The invention provides a pharmaceutical composition for the treatment of a mammal having a skin disease. The composition contains a serine protease inhibitor and an effective amount of a cationic quaternary ammonium salt at a concentration below the critical micelle concentration for increasing the penetration of the inhibitor in the skin. Additionally, these may be included an ethoxylated nonylphenol.

REFERENCES:
patent: 5008242 (1991-04-01), Lezdey
patent: 5134119 (1992-07-01), Lezdey
patent: 5166134 (1992-11-01), Lezdey
patent: 5190917 (1993-03-01), Lezdey
patent: 5217951 (1993-06-01), Lezdey
Hubbard et al, "Biochemical Efficacy and Safety of Monthly Augmentation Therapy for Alpha 1-Antitrypsin Deficiency" JAMA, vol. 260, No. 9, Sep. 2, 1988.
Remington Pharmaceutical Sciences p. 730, 1159, 1985.

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