Topical administration of catecholamines and related compounds t

Details Topical administration of catecholamines and related compounds t Topical administration of catecholamines and related compounds t

1997-05-05

1999-03-09

Venkat, Jyothsna

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Cosmetic, antiperspirant, dentifrice

514944, 424DIG5, A61K 748

Patent

active

058796908

ABSTRACT:
Compositions for the topical treatment of sagging subcutaneous muscle and overlying cutaneous tissue contain an active ingredient exhibiting or producing catecholamine activity such as catecholamines and/or related compounds in a dermatologically acceptable carrier that contains at least one percutaneous penetration enhancer. Examplary catecholamines include adrenaline, norepinepherine, dopamine and their precursors; catecholamine precursors such as tyrosine and phenylalanine are preferred. Many embodiments, particularly those employing tyrosine and/or phenylalanine as a catecholamine precursor, further contain a neurotransmitter synthesis enhancer such as dimethylaminoethanol, and other co-factors such as vitamin B.sub.6 and pantothenic acid or calcium pantothenate are included in the composition to enhance the action of the active ingredients. Other compounds that scavenge free radicals and antioxidants may also be added.

REFERENCES:
patent: 4590067 (1986-05-01), Meisner
patent: 4647453 (1987-03-01), Meisner
patent: 4772591 (1988-09-01), Meisner
patent: 4938969 (1990-07-01), Schinitsky et al.
patent: 5376361 (1994-12-01), Perricone
patent: 5554647 (1996-09-01), Perricone
Smith, E. W. and Maiback H. I.,"Percutaneous Penetration Enhancers", 1995, Book pp. 1-405.

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