Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 8 to 10 amino acid residues in defined sequence
Reexamination Certificate
2000-08-17
2008-08-05
Chernyshev, Olga N (Department: 1649)
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
8 to 10 amino acid residues in defined sequence
C530S387100, C435S337000, C435S345000, C424S130100
Reexamination Certificate
active
07408027
ABSTRACT:
The invention relates to epitopes of the tau protein which are specifically occurring in a phosphorylated state in tau protein from Alzheimer paired helical filaments, to protein kinases which are responsible for the phosphorylation of the amino acids of the tau protein giving rise to said epitopes, and to antibodies specific for said epitopes. The invention further relates to pharmaceutical compositions for the treatment or prevention of Alzheimer's disease, to diagnostic compositions and methods for the detection of Alzheimer's disease and to the use of said epitopes for the generation of antibodies specifically detecting Alzheimer tau protein. Additionally, the invention relates to methods for testing drugs effective in dissolving Alzheimer paired helical filaments or preventing the formation thereof.
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Biernat Jacek
Drewes Gerard
Lichtenberg-Kraag Birgit
Mandelkow Eckhard
Mandelkow Eva-Maria
Chernyshev Olga N
Marshall & Gerstein & Borun LLP
Max-Planck-Gesellschaft zur Forderung der Wissenchaften
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