Tools for the diagnosis and treatment of Alzheimer's disease

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...

Reexamination Certificate

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C530S387100, C530S389100, C530S387900, C530S388500, C435S326000, C435S331000

Reexamination Certificate

active

10066810

ABSTRACT:
The present invention relates to phosphorylated tau protein epitopes associated with Alzheimer's disease, to protein kinases responsible for tau protein epitope phosphorylation, and to antibodies specific for the tau epitopes. Additionally, the present invention relates to pharmaceutical compositions, methods for detection, and methods of testing drugs effective in dissolving paired helical filaments associated with Alzheimer's disease.

REFERENCES:
patent: 475 295 (1991-11-01), None
patent: WO 89/03993 (1989-05-01), None
patent: WO 93/03148 (1993-02-01), None
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