Image analysis – Applications – Biomedical applications
Reexamination Certificate
2002-05-10
2004-02-24
Boudreau, Leo (Department: 2621)
Image analysis
Applications
Biomedical applications
C382S255000, C378S004000
Reexamination Certificate
active
06697508
ABSTRACT:
FIELD OF THE INVENTION
The present invention relates to three-dimensional (3D) imaging systems in general, and, more particularly to three-dimensional (3D) imaging systems using a priori knowledge about an object of interest that is undergoing image reconstruction using computed tomography.
BACKGROUND OF THE INVENTION
Image reconstruction algorithms in use today compute the typically three-dimensional (3D) structure of an object from its one or two-dimensional projections without using additional information about the object. Known reconstruction algorithms in the tomography field, and especially the optical tomography field, are deficient in the use of a priori knowledge for enhancing object reconstruction.
SUMMARY OF THE INVENTION
In one embodiment, the present invention provides a method for three-dimensional (3D) reconstruction of an object of interest, such as a cell, including adjusting a current set of projection images according to a priori knowledge to produce adjusted projection images, for example, based on simple probability masks or Bayesian analysis of multiple similar objects in the same sample. A reconstruction algorithm is used on the adjusted projection images to generate a 3D image. The 3D image is further adjusted according to the a priori knowledge to generate an adjusted 3D image. Criteria for process completion are applied to determine whether the adjusted 3D image is adequate. Otherwise, a set of pseudo projections are computationally created at the same projection angles as the current set of projection images and then compared to the current set of projection images to produce a more realistic set of new projections, wherein the new projections are input again to the reconstruction algorithm and the steps of the method are repeated until the adequacy criteria are met.
REFERENCES:
patent: 3470373 (1969-09-01), Brewer
patent: 3497690 (1970-02-01), Wheeless, Jr.
patent: 3657537 (1972-04-01), Wheeless, Jr.
patent: 3833762 (1974-09-01), Gudmundsen
patent: 3960449 (1976-06-01), Carleton
patent: 3999047 (1976-12-01), Green
patent: 4175860 (1979-11-01), Bacus
patent: 4293221 (1981-10-01), Kay
patent: 4360885 (1982-11-01), Edgar
patent: 4873653 (1989-10-01), Grosskopf
patent: 5141609 (1992-08-01), Sweedler et al.
patent: 5148502 (1992-09-01), Tsujiuchi et al.
patent: 5281517 (1994-01-01), Bacus et al.
patent: 5308990 (1994-05-01), Takahashi et al.
patent: 5312535 (1994-05-01), Waska et al.
patent: 5402460 (1995-03-01), Johnson et al.
patent: 5668887 (1997-09-01), Parker et al.
patent: 5680484 (1997-10-01), Ohyama et al.
patent: 5741411 (1998-04-01), Yeung et al.
patent: 5828408 (1998-10-01), Mottin et al.
patent: 5848123 (1998-12-01), Strommer
patent: 5878103 (1999-03-01), Sauer et al.
patent: 5909476 (1999-06-01), Cheng et al.
patent: 5987158 (1999-11-01), Meyer
patent: 6005617 (1999-12-01), Shimamoto et al.
patent: 6026174 (2000-02-01), Palcic
patent: 6047080 (2000-04-01), Chen et al.
patent: 6130958 (2000-10-01), Rohler et al.
patent: 6165734 (2000-12-01), Garini
patent: 6201628 (2001-03-01), Basiji
patent: 6211955 (2001-04-01), Basiji
patent: 6248988 (2001-06-01), Krantz
patent: 6249341 (2001-06-01), Basiji
patent: 6251586 (2001-06-01), Mulshine
patent: 6251615 (2001-06-01), Oberhardt
patent: 6252979 (2001-06-01), Lee
patent: 2001/0012069 (2001-08-01), Derndinger et al.
patent: 2002/0161534 (2002-10-01), Adler et al.
Kikuchi, S. et al., “Three-dimensional computed tomography for optical microscopes,” Optics Communications 107 (1994) 432-444.
Kikuchi, S. et al., “Three-dimensional microscopic computed tomography based on general Radon transform for optical imaging systems,” Optics Communications 123 (1996).
Matula, P. et al. “Precise 3D image alignment in micro-axial tomography,” Journal of Microscopy, vol. 209, Pt. 2 (Feb. 2003) pp. 126-142.
Shapiro, HM,Practical Flow Cytometry,3rded., Wiley-Liss, 1995.
Gilbert, P, “Iterative Methods for the Three dimensional Reconstruction of an Object from Projections,” Journal of Theoretical Biology 36:105-17, 1972.
Oppenheim, BE, 'More Accurate Algorithms for Iterative 3 dimensional Reconstruction, IEEE Transactions on Nuclear Science NS-21:72-7, 1974.
Singer, JR, Grunbaum, FA, Kohn, P, and Zubelli, JP, “Image Reconstruction of the Interior of Bodies that Diffuse Radiation,” Science 248(4958):990-3, 1990.
Mueller, K and Yage, R, “Rapid 3-D Cone-beam Reconstruction with the Simultaneous Algebraic Reconstruction Technique (SART) Using 2-D Texture Mapping Hardware”, IEEE Transactions on Medical imaging 19(12):1227-37, 2001.
Bellman, SH, Bender, R, Gordon, R, and Rowe, JE, “ART is Science being A Defense of Algebraic Reconstruction Techniques for Three dimensional Electron Microscopy,” Journal of Theoretical Biology 32:205-16, 1971.
Manglos, SH, Jaszcak, RJ, and Floyd, CE, “Maximum Likelihood Reconstruction for Cone Beam SPECT: Development and Initial Tests,” Physics in Medicine and Biology 34(12):1947-57, 1989, #1382.
Manglos, SH, Gagne, GM, Krol A, Thomas, FD, and Narayanaswamy, R, “Transmission Maximum-likelihood Reconstruction with Ordered Subsets for Cone Beam CT”, Physics in Medicine and Biology 40(7):1225-41, 1995, #4389.
Hampel, U and Freyer, R, “Fast Image Reconstruction for Optical Absorption Tomography in Media with Radially Symmetric Boundaries”, Medical Physics 25 (1):92-101, 1998.
Jiang, H, Paulsen, KD, and Osterberg, UL, “Frequency-domain Near-infrared Photo Diffusion Imaging: Initial Evaluation in Multitarget Tissuelike Phantoms”, Medical Physics 25(2):183-93, 1998.
Herman, G,Image Reconstruction from Projections: The Fundamentals of Computerized Tomography,Academic Press, New York, 1980.
Paulsen, KD and Jiang, H, “Spatially Varying Optical Property Reconstruction Using a Finite Element Diffusion Equation Approximation”, Medical Physics 22(691-701) 1995.
Boudreau Leo
Leone George A.
Sherali Ishrat
VisionGate, Inc.
LandOfFree
Tomographic reconstruction of small objects using a priori... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Tomographic reconstruction of small objects using a priori..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Tomographic reconstruction of small objects using a priori... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3287202