Toll-like receptor 4 mutations

Details Toll-like receptor 4 mutations Toll-like receptor 4 mutations

2005-07-05

2005-07-05

Andres, Janet (Department: 1646)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

C435S007100, C435S069100, C530S350000

Reexamination Certificate

active

06913888

ABSTRACT:
The present invention relates, in general, to toll-like receptor 4 (TLR4) mutations and, in particular, to a method of assessing the susceptibility of an individual to atherosclerosis and to a method of treating an individual identified as being at increased risk.

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patent: WO 00/77204 (2000-12-01), None
patent: WO 01/55386 (2001-08-01), None
Smirnova et al, “Phylogenetic variation and polymorphism at the Toll-like receptor 4 locus (TLR4)”, Genome Biology 1(1):1-10 (2000).
Xu et al, “Toll-Like Receptor-4 Is Expressed by Macrophages in Murine and Human Lipid-Rich Atherosclerotic Plaques and Upregulated by Oxidized LDL”, Circulation 104:3103-3108 (2001).
Equils et al, “Bacterial Lipopolysaccharide Activates HIV Long Terminal Repeat Through Toll-Like Receptor 4”, The Journal of Immunology 166:2342-2347 (2001).
Franchin et al, “Lipopolysaccharide Inhibits HIV-1 Infection of Monocyte-Derived Macrophages Through Direct and Sustained Down-Regulated of CC Chemokine Receptor 5”, The Journal of Immunology 164:2592-2601 (2000).
Kiechl et al, “Toll-Like Recerptor 4 Polymorphisms and Atherogenesis”, N. Engl. J. Med. 347(3):185-192 (2002).

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