Toll/interleukin-1 receptor adapter protein (TIRAP)

Details Toll/interleukin-1 receptor adapter protein (TIRAP) Toll/interleukin-1 receptor adapter protein (TIRAP)

2007-10-23

2007-10-23

Wax, Robert A. (Department: 1652)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C514S012200, C530S327000, C530S324000

Reexamination Certificate

active

11229066

ABSTRACT:
TIRAP polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing TIRAP polypeptides and polynucleotides in therapy, and diagnostic assays for such.

REFERENCES:
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patent: 7029861 (2006-04-01), Beutler et al.
patent: 2002/0164640 (2002-11-01), Sims et al.
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patent: WO 00/41561 (2000-07-01), None
patent: WO 00/60080 (2000-10-01), None
patent: WO 01/88137 (2001-11-01), None
Hardiman, G., et al., “Genetic Structure and Chromosomal Mapping of MyD88,”Genomics,45(2):332-339 (Oct. 15, 1997).
Horng, T., et al., “TIRAP: An Adapter Molecule in the Toll Signaling Pathway,”Nature Immunology,2(9): 835-841 (Sep. 2001).
Means, T.K., et al., “Differential Effects of a Toll-Like Receptor Antagonist onMycobacterium tuberculosis-Induced Macrophage Responses,”Journal of Immunology,166(6):4074-4082 (Mar. 15, 2001).
Bonnert, T.P., et al., “The Cloning and Characterization of Human MyD88: a Member of an IL-1 Receptor Related Family,”FEBS Lett.,402(1):81-84 (1997).
Fitzgerald, K.A., “Mal (MyD88-adapter-like) is Required for Toll-like Receptor-4 Signal Transduction,”Nature 413(6851):78-83 (2001).
Hardiman, et al., “Molecular Characterization and Modular Analysis of HumanMyD88,” Oncogene 13(11):2467-2475 (1996).
Lord, et al., “Nucleotide Sequence and Expression of a cDNA Encoding MyD88, a Novel Myeloid Differentiation Primary Response Gene Induced by IL6,”Oncogene 5(7):1095-1097 (1990).
Sigmund, et al., “Viewpoint: Are Studies in Genetically Altered Mice out of Control?,”Arterioscler. Thromb. Vasc. Biol. 20:1428-1429 (2000).
Result 7 of sequences search in Geneseq database, alignment with SEQ ID No. 11 of DE 19526174 A1, printed on Apr. 26, 2005.
Result 1 of sequence search in US issued patents database, alignment with SEQ ID No. 2 of US 6,399,584 printed on Apr. 26, 2005.

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